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== Phosphatidylinositol 4-Phosphate-5 kinase (PI4P5K) or PIP5K or PI5K family regulates diverse cellular processes such as G protein-coupled receptors (GPCR) signaling, vesicle trafficking, chemotaxis and cellular movement [1][2][3]. There are at least two types of PIP5K found which includes Type I and Type II. Other types are also suspected in the nervous system but have not been well reported. These enzyme synthesize diverse Phosphatidyl Inositol 4,5 bisphosphate ( PI(4,5)P2 ) by phosphorylating the D- 5 position of the inositol ring of Phosphatidylinositol 4-phosphate[3]. PIP5KI is the most extensively studied and is synthesizing for most of the PI(4,5)P2 pool the cell[4][5].