Talk:PMSF

Latest comment: 14 years ago by Pelirojopajaro in topic Toxic

anyone know the half life of PMSF in DMSO? and at what temp it should be stored? —Preceding unsigned comment added by 128.255.232.66 (talk) 15:04, 8 August 2008 (UTC)Reply

It's stable for about 9 months at 4C. You can find more info about it on the Sigma-Aldrich site. But be very careful: I'm sure you know DMSO will take it right through your skin. Isopropanol could be a better choice. 199.76.144.85 (talk) 15:47, 14 August 2008 (UTC)Reply

Toxic edit

I've always been taught that PMSF is very toxic because it is an acetylcholinesterase inhibitor, a la VX Nerve Gas. But at a LD50 of 500mg/kg, it's lethality is less than that of caffeine or asprin, what gives? Adenosinetalk 00:13, 11 November 2009 (UTC)Reply

It depends on how it gets into your body. if you swallow it it will probably just inhibit trypsin and chymotrypsin. Going straight to your brain could be a little different Pelirojopajaro (talk) 18:19, 1 March 2010 (UTC)Reply