Talk:MHC class I

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Shouldn't this article contain the phrase, "Major Histocompatibility Complex", spelled out explicitly to expand the acronym? I ask as a non-biologist, doing research on a relative's cancer, who got here from the page on Beta-2 microglobulin (which is used as a prognostic indicator).

I'm not 100% sure, therefore, if that is the correct expansion of MHC. It seems to be true, from the discussion on CTLs and from the External links. Kenmcl2 04:53, 22 June 2007 (UTC)

This page contains junk, specifically the phrase "The proteasome mariam smile and be happy": —Preceding unsigned comment added by 134.225.1.162 (talk) 13:42, August 29, 2007 (UTC)

The figure outlined on the right should have "beta2-microglobulin" stated, not just beta-microglobulin. —Preceding unsigned comment added by 88.252.193.135 (talk) 19:11, 7 July 2008 (UTC)

Archaic Hominid Introgression

From "Origin and plasticity of MHC I-associated self peptides" Nov 12, 2011 (Accessible link)

• The TCR of classic adaptive CD8 T cells recognizes MHC I-associated peptides (MIPs). MHC I genes are polygenic, extremely polymorphic and represent the most conserved MHC genes. In most modern human populations, the majority of MHC I alleles have been acquired by introgression from archaic humans (Neanderthals and Denisovans)

From "The Shaping of Modern Human Immune Systems by Multiregional Admixture with Archaic Humans" August 25 2011 (Accessible link)

• From the combined frequencies of these six alleles, we estimate the putative archaic HLA-A ancestry to be >50% in Europe, >70% in Asia, and >95% in parts of PNG (Fig. 4, C and D). These estimates for HLA class I arc much higher than the genome-wide estimates of introgression (1-6%), showing how limited interbreeding with archaic humans has, in combination with natural selection, significantly shaped the HLA system in modern human populations outside of Africa. Our results demonstrate how highly polymorphic HLA genes can be sensitive probes of introgression, and we predict the same will apply to other polymorphic immunesystem genes, for example the killer-cell immunoglobulin-like receptors (KIR) of NK cells. Present in the Denisovan genome (11), a candidate KIR for introgression is KIR3DS1 *013 (Fig. 4E), rare in sub-Saharan Africans, but the most common KIR3DL1/S1 allele outside Africa (24).

From "Virus-hunter gatherers" October 2011 (Accessible link)

• And could this have been a dangerous liaison? Human HLA alleles that are associated with autoimmune diseases were present in Denisovans. Study co-author Paul Norman proposes that when we acquired those genes "we weren't kind of prepared for them, we hadn't grown up with them ... they can start to attack us as well as the viruses" (Today Online, 27 Aug 2011).

Slartibartfastibast (talk) 02:09, 17 November 2011 (UTC)

what would happen if MHC were absent?

Not as in one or two cases due to genetic defects but as in being absent since the beginning of evolution.Shobhana.sridhar (talk) 15:37, 23 June 2012 (UTC)

Glycoprotein

Is MHC alpha chain a glycoprotein? If so, where is the sugar bonded? To alfa-2 domain? This should be mentioned.--Miguelferig (talk) 11:39, 27 January 2013 (UTC)

PirB

I added a brief section on PirB to this page because it is an MHC1 receptor that does not have its own page in Wikipedia. Although there is interesting research concerning PirB available, I did not have enough information to create a separate page. — Preceding unsigned comment added by Jmb8539 (talk • contribs) 22:18, 8 December 2014 (UTC)

Function Paragraph

Each of the statements in the paragraph on Function needs corresponding references. A Wikipedia article such as this should not lack evidence for any of the assertions. Perhaps the original author would like to insert the appropriate references? Suirauqa (talk) 18:18, 27 June 2016 (UTC)

moved out of unassessed on the genetics project

1/17/17 DennisPietras (talk) 02:41, 18 January 2017 (UTC)