Talk:Inhibin

I don't get the merger proposition

They're two completely different things - somewhat related, yes, but still totally different. I don't even see a reason that they would be merged. Fantumphool (talk) 06:37, 23 February 2008 (UTC)

I had put the merge proposal there because two of the infoboxes on activin and inhibin have the same Entrez Gene IDs. Leads me to believe that they are synonyms and that these pages should be merged. Thoughts? AndrewGNF (talk) 14:54, 23 February 2008 (UTC)

It looks to me that the IDs are one off from each other? 3623 versus 3624? I don't know about that, but they have opposing actions, I am pretty sure, on the release of FSH. They are related in this way, but I think that they are structurally different. Fantumphool (talk) 16:01, 28 February 2008 (UTC)

Activin has two protein boxes, IDs 3624 and 3625. Inhibin has three protein boxes, 3623, 3624, and 3625. Also, notice that the official title for 3624 is "inhibin, beta A (activin A, activin AB alpha polypeptide)". I think this is an example of a confusing case of synonyms... AndrewGNF (talk) 16:22, 28 February 2008 (UTC)

As per the above discussion, I am removing the merger proposition. If you disagree, you can put it back. —Preceding unsigned comment added by Fantumphool (talk • contribs) 15:33, 10 April 2008 (UTC)

I'm confused. I stated my rationale above (specifically, "Activin has two protein boxes, IDs 3624 and 3625. Inhibin has three protein boxes, 3623, 3624, and 3625") that they clearly overlap to a significant degree. Before removing the merge tags again, let's discuss here? AndrewGNF (talk) 16:04, 10 April 2008 (UTC)

Sorry, I guess I didn't see your rationale above (I'm not sure how?). Anyway, here's the thing: both article mention that they have opposing effects. Maybe they're made of the same primary structures, but have different tertiary structures? I don't actually know, so I am a bit out of my knowledge on that. I think we need an expert on the subject. Here's what the entrez gene description for 3624 has to say:

(http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=retrieve&dopt=default&rn=1&list_uids=3624)

"Furthermore, the beta A subunit forms a homodimer, activin A, and also joins with a beta B subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion."

It sounds to me that maybe they're made from the same gene, but are chopped up differently to make different products. Bottom line, I don't know, but I still think they're different. And, I give up.Fantumphool (talk) 21:39, 26 May 2008 (UTC)

they are different. have 1 article that links to 2 other articles. but they need separate articles. 207.151.241.35 (talk) 20:04, 21 September 2008 (UTC)

Difference between activin and inhibin

Hi. According to the Online Mendelian Inheritance in Man (OMIM): 147290 who in turn cites Burger HG, Igarashi M (1988). "Inhibin: definition and nomenclature, including related substances". J. Clin. Endocrinol. Metab. 66 (4): 885–6. PMID 3346366. {{cite journal}}: Unknown parameter |month= ignored (help):

activin and inhibin are derived from identical genes and proteins but differ only in their aggregation state. The inhibins appear to be monomeric whereas activins are dimeric. More specifically:

• the 2 (monomeric) forms of the inhibin beta subunit are referred to as inhibin beta-A and inhibin beta-B
• the beta dimer of inhibin, which stimulates FSH secretion, should be called activin
• homodimer of the beta-A subunit is to be termed activin A
• heterodimer consisting of 1 beta-A and 1 beta-B subunit termed activin A-B.

I think these two pages should be merged since they deal with the same genes and proteins. The introduction of the merged article should explain what the difference between activin and inhibin is. Furthermore separate subsections dealing with the opposing activities of activin and inhibin could then be added. Does this sound reasonable? Cheers. Boghog2 (talk) 19:48, 24 December 2008 (UTC)