Talk:Apelin receptor

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Mutated in some melanoma

Latest comment: 6 years ago1 comment1 person in discussion

[1] (report on Nature article) says "The team next focused on one gene, APLNR, which codes for the apelin receptor, a G protein-coupled receptor (GPCR) that hadn’t previously been associated with T-cell killing of cancer, but which is known to be mutated in a number of different tumor types. They identified seven different mutations in this gene in the genetic makeup of metastatic melanoma and lung cancer patients who had failed therapy using immune checkpoint inhibitors." - Rod57 (talk) 17:39, 16 August 2017 (UTC)Reply

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