Wiki Education Foundation-supported course assignment

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  This article was the subject of a Wiki Education Foundation-supported course assignment, between 23 August 2021 and 10 December 2021. Further details are available on the course page. Student editor(s): Jcorelite.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 17:18, 17 January 2022 (UTC)Reply

Untitled

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PLEASE cite information when you add it to this article, or any other for that matter! Kilbad 00:47, 28 July 2007 (UTC)Reply

Wiki Education Foundation-supported course assignment

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  This article was the subject of a Wiki Education Foundation-supported course assignment, between 3 September 2019 and 12 December 2019. Further details are available on the course page. Student editor(s): SamTheBioGal.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 14:16, 16 January 2022 (UTC)Reply

WikiProject class rating

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This article was automatically assessed because at least one WikiProject had rated the article as start, and the rating on other projects was brought up to start class. BetacommandBot 16:23, 10 November 2007 (UTC)Reply

Renal Effects

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I've got it right here in my textbook (Medical Physiology, Boron and Boulpaep 2005) that the net renal effect of ATII is to DECREASE glomerular filtration rate, not increase it as the article currently states. --AaronM (talk) 16:48, 19 March 2008 (UTC)Reply

ATII constricts the efferent arteriole *increasing* the GFR. The action of an ACE inhibitor will decrease GFR (but will maintain perfusion of the vasa recta and other tissues) Falconerd (talk) 05:29, 27 September 2012 (UTC)Reply

More correctly, low(er) levels of ATII preferentially constrict the efferent arteriole, increasing the GFR. At high enough levels of ATII, total resistance will be so high that total GFR will actually decrease.130.132.173.48 (talk) 04:33, 3 November 2014 (UTC)Reply

As I understand things, Angiotensin has been factored out to seven levels recently. A1-A7.

"Broken" reference

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Reference #3 - ^ Physiology at MCG 7/7ch09/7ch09p16 - leads me to a 403 error:

Forbidden - You don't have permission to access /edu/eshuphysio/program/section7/7ch09/7ch09p16.htm on this server.

This article could be referenced instead. --Monsieur.lefou (talk) 15:23, 20 September 2011 (UTC)Reply

How to mention drug formulations and approvals

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Eg Giapreza redirects here but it is not mentioned. It is an IV angiotensin II - could mention brand names under each type - or perhaps in a separate section Proprietary formulations or As medical therapy ? - Rod57 (talk) 12:44, 4 March 2018 (UTC)Reply

There don't seem to be a lot of different formulations or brands of angiotensin II and the other forms (angiotensin I, III, and IV) do not seem to have been used as drugs. As each form of angiotensin is a distinct molecular entity, if Giapreza were mentioned in this article, it should be under the angiotensin II section. However because of conflicts between WP:MCBMOS and WP:MEDMOS, I think it would be better to split out angiotensin II (medication) as a separate article. Boghog (talk) 17:26, 4 March 2018 (UTC)Reply
I took the liberty of creating angiotensin II (medication). I hope this is OK. Boghog (talk) 20:40, 4 March 2018 (UTC)Reply

Adding Angiotensinogen Information

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Hi all, I'm working on this page for a school project. I have some edits on the angiotensinogen portion that I'm planning to update. They're included below in case someone has comments before I go making changes.

Angiotensinogen is synthesized in the liver[1] and is a precursor for angiotensin, but has also been indicated as having many other roles not related to angiotensin peptides.[2] It is a member of the serin family of proteins, leading to another name: Serin A8[3]. In addition, a generalized crystal structure can be estimated by examining other proteins of the serin family, but angiotensinogen has an elongated N-terminus compared to other serin family proteins.[4] Angiotensinogen is cleaved at the N-terminus by renin to result in angiotensin I, which will later be modified to become angiotensin II.[2][4] This peptide is 485 amino acids long, and 10 N-terminus amino acids are cleaved when renin acts on it.[2]


"Angiotensin | Hormone Health Network". www.hormone.org. Retrieved 2019-10-11.
Lu, Hong; Cassis, Lisa A.; Kooi, Craig W. Vander; Daugherty, Alan (February 2016). "Structure and functions of angiotensinogen". Hypertension Research. 39 (7): 492–500. doi:10.1038/hr.2016.17. ISSN 1348-4214.
"AGT - Angiotensinogen precursor - Homo sapiens (Human) - AGT gene & protein". www.uniprot.org. Retrieved 2019-10-09.
Streatfeild-James, Rosa M. A.; Williamson, David; Pike, Robert N.; Tewksbury, Duane; Carrell, Robin W.; Coughlin, Paul B. (1998). "Angiotensinogen cleavage by renin: importance of a structurally constrained N-terminus". FEBS Letters. 436 (2): 267–270. doi:10.1016/S0014-5793(98)01145-4. ISSN 1873-3468.

Thanks! SamTheBioGal (talk) 00:22, 2 December 2019 (UTC)Reply


Hello all, I am also working on this page for a school project. Here is the bibliography (in ACS citation) for my sources:

(1) Padia, S. H.; Howell, N. L.; Siragy, H. M.; Carey, R. M. Renal Angiotensin Type 2 Receptors Mediate Natriuresis Via Angiotensin III in the Angiotensin II Type 1 Receptor–Blocked Rat. Hypertension. 2006, 47 (3), 537-544. DOI: 10.1161/01.HYP.0000196950.48596.21 (2) Lu, H.; Cassis, L. A.; Vander Kooi, C. W.; Daugherty, A. Structure and Functions of Angiotensinogen. Hypertension Research. 2016, 39, 492-500. DOI: https://doi-org.aurarialibrary.idm.oclc.org/10.1038/hr.2016.17 (3) Ho, J. K.; Nation, D. A. Cognitive Benefits of Angiotensin IV and Angiotensin-(1–7): A Systematic Review of Experimental Studies. Neuroscience and Biobehavioral Reviews. 2018, 92, 209-225. DOI: https://doi.org/10.1016/j.neubiorev.2018.05.005 Thank you! Jcorelite (talk) 02:36, 15 October 2021 (UTC)Reply

Error in PDB codes

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The list of PDB codes for AGT's infobox (currently) looks like this: 2WXW, 2X0B, 4APH,%%s1N9U, 1N9V,%%s1N9V, 1N9U, 3CK0, 4AA1, 4APH, 5E2Q. Note the %%s leading two of the codes. I checked the source at http://www.rcsb.org/pdb/results/results.do?tabtoshow=Current&qrid=834DF9F1, and found it wasn't the source of extraneous symbols. So it might be in the infobox, but more likely it's something in wikidata. The wikidata entry for AGT is very large, and a quick search didn't reveal where PDB codes are drawn from. I'm hoping someone more familiar with the subject content will know what's up with the PDB codes. Prime Lemur (talk) 23:05, 5 May 2020 (UTC)Reply