Talk:3α-Hydroxysteroid dehydrogenase

Rename from "3α-Hydroxysteroid dehydrogenase" to "3α-Hydroxysteroid dehydrogenase type 1"

I consider important to rename this article from "3α-Hydroxysteroid dehydrogenase" to "3α-Hydroxysteroid dehydrogenase type 1"

The reason is because this article is about type 1 of the 3α-Hydroxysteroid dehydrogenase, not about all the isozymes.

There are 3 isoforms of 3α-Hydroxysteroid dehydrogenase, and only the type 1 is encoded by AKR1C4 gene. However, the article tells that this protein is encoded by the AKR1C4 gene in humans, suggesting that it is about the type 1 of 3α-Hydroxysteroid dehydrogenase.

The rename addresses the ambiguity, i.e. is a disambiguator. See https://en.wikiversity.org/wiki/WikiJournal_of_Medicine/Alternative_androgen_pathways#Enzymes for the other isozymes. Maxim Masiutin (talk) 09:56, 8 April 2024 (UTC)

Requested move 9 April 2024

3α-Hydroxysteroid dehydrogenase → AKR1C4 – This article covers the type 1 isoform of the enzyme, which is encoded by the gene AKR1C4. The current title is ambiguous with the other isoforms of this enzyme, which each have an article under the name of the gene which encode them (AKR1C2, AKR1C3). This title could be made more precise by lengthening it to 3α-Hydroxysteroid dehydrogenase type 1. However, to make it more concise and consistent as well, I propose moving the page to AKR1C4 (which was the title until 2012). SilverLocust 💬 19:39, 9 April 2024 (UTC) — Relisting. Natg 19 (talk) 23:21, 18 April 2024 (UTC)

Continued from a technical move request. Pinging @Maxim Masiutin. SilverLocust 💬 19:43, 9 April 2024 (UTC)

I first proposed to Rename from "3α-Hydroxysteroid dehydrogenase" to "3α-Hydroxysteroid dehydrogenase type 1" on this Talk page, but @SilverLocust mentioned that earlier name of this page was AKR1C4 and suggested to rename to AKR1C4. I agree that is a better name. Therefore, I'm in favour of renaming from "3α-Hydroxysteroid dehydrogenase" to "AKR1C4". Maxim Masiutin (talk) 20:09, 9 April 2024 (UTC)

Maybe in the future we will create a kind of list page for "3α-Hydroxysteroid dehydrogenase" that will cover all isozymes, not particularly type 1 or 2 or 3, but at this momemnt I'm just in favor of renaming.

By the way, how can I get all the Wikipedia pages that link to "3α-Hydroxysteroid dehydrogenase" (3α-Hydroxysteroid dehydrogenase) directly? I would like to check and edit these pages to figure out whther they refer to a group of isozymes or a particular isozyme. Maxim Masiutin (talk) 20:12, 9 April 2024 (UTC)

Special:WhatLinksHere/3α-Hydroxysteroid_dehydrogenase. SilverLocust 💬 20:39, 9 April 2024 (UTC)

I also support the move procedure via {{subst:requested move}} template. This is a longer procedure, but we are not in a hurry. This procedure leaves the trace and the explanation on the Talk page (it's better to not move this discussion to archive) so that the other editors may see the reason behind the move and it will prevent them from raising issues again without first analyzing prior move history and the reasoning. Maxim Masiutin (talk) 20:19, 9 April 2024 (UTC)

I reviewed some ot the pages that link to "3α-Hydroxysteroid dehydrogenase" and figured out that often the context does apply to all isoforms of 3α-hydroxysteroid dehydrogenase or to the enzymatic reaction without knowing the exact isoforms. Therefore, if the move will be approved, after the move I will create a page "3α-Hydroxysteroid dehydrogenase" that will be applicable to all isoforms.Maxim Masiutin (talk) 05:26, 10 April 2024 (UTC)

Can we consider that consensus on rename is reached now and move the page, as no objections came in 7 days? Maxim Masiutin (talk) 05:54, 17 April 2024 (UTC)

Please wait for it to be closed (or relisted for more input) by an uninvolved editor. SilverLocust 💬 08:47, 17 April 2024 (UTC)

By the way, if the rename proposal passes, I will create a new article "3α-Hydroxysteroid dehydrogenase" which will not be related to a particular isozyme encoded by a particular gene such as it is now, but by a group of enzymes with similar functions regardless of the gene that encodes it, because in the organism sometimes several isozymes are involved.

Please also let me know what term should we wait until a rename decision can be made? Maxim Masiutin (talk) 03:13, 4 May 2024 (UTC)

Note: WikiProject Molecular Biology has been notified of this discussion. Natg 19 (talk) 23:24, 18 April 2024 (UTC)