TSSM may refer to:
- Titan Saturn System Mission
- Type III secretion machinery
- Two-spotted spider mite
- The Spectacular Spider-Man
- The SpongeBob SquarePants Movie, particularly the video game of the same name
This disambiguation page lists articles associated with the title TSSM.
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If an internal link led you here, you may wish to change the link to point directly to the intended article.