TRPM4

Transient receptor potential cation channel subfamily M member 4 (hTRPM4), also known as melastatin-4, is a protein that in humans is encoded by the TRPM4 gene.

TRPM4
Identifiers
Aliases	TRPM4, PFHB1B, TRPM4B, LTrpC4, htransient receptor potential cation channel subfamily M member 4, EKVP6
External IDs	OMIM: 606936; MGI: 1915917; HomoloGene: 23033; GeneCards: TRPM4; OMA:TRPM4 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.33 Start 49,157,741 bp End 49,211,836 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 B3 Start 44,952,056 bp End 44,983,204 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon rectum apex of heart minor salivary glands right uterine tube skin of leg skin of abdomen Descending thoracic aorta gallbladder left lobe of thyroid gland Top expressed in jejunum duodenum colon ileum vestibular membrane of cochlear duct lip left colon muscle of thigh stomach esophagus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding calcium channel activity calmodulin binding ion channel activity ATP binding sodium channel activity calcium activated cation channel activity calcium ion binding metal ion binding Cellular component integral component of membrane Golgi apparatus membrane plasma membrane nucleoplasm endoplasmic reticulum cytosol soma sodium channel complex spanning component of plasma membrane spanning component of membrane Biological process adaptive immune response vasoconstriction immune system process positive regulation of canonical Wnt signaling pathway regulation of membrane potential cation transport ion transport protein sumoylation dendritic cell chemotaxis regulation of T cell cytokine production cardiac conduction positive regulation of cell population proliferation calcium ion transport negative regulation of bone mineralization positive regulation of atrial cardiac muscle cell action potential positive regulation of heart rate transmembrane transport positive regulation of adipose tissue development positive regulation of cytosolic calcium ion concentration calcium ion transmembrane transport positive regulation of fat cell differentiation positive regulation of insulin secretion involved in cellular response to glucose stimulus negative regulation of osteoblast differentiation positive regulation of vasoconstriction positive regulation of regulation of vascular associated smooth muscle cell membrane depolarization ion transmembrane transport calcium-mediated signaling membrane depolarization during AV node cell action potential membrane depolarization during Purkinje myocyte cell action potential membrane depolarization during bundle of His cell action potential regulation of heart rate by cardiac conduction sodium ion import across plasma membrane regulation of ventricular cardiac muscle cell action potential protein homotetramerization cellular response to ATP inorganic cation transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54795 68667 Ensembl ENSG00000130529 ENSMUSG00000038260 UniProt Q8TD43 Q7TN37 RefSeq (mRNA) NM_001195227 NM_017636 NM_001321281 NM_001321282 NM_001321283 NM_001321285 NM_175130 RefSeq (protein) NP_001182156 NP_001308210 NP_001308211 NP_001308212 NP_001308214 NP_060106 NP_780339 Location (UCSC) Chr 19: 49.16 – 49.21 Mb Chr 7: 44.95 – 44.98 Mb PubMed search
Wikidata
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TRPM4 Channel Blocker

• 9-Phenanthrol
• TRPM4-IN-5

See also

• TRPM

Further reading

• Islam, Md. Shahidul (January 2011). Transient Receptor Potential Channels. Advances in Experimental Medicine and Biology. Vol. 704. Berlin: Springer. p. 700. ISBN 978-94-007-0264-6.
• Launay P, Fleig A, Perraud AL, Scharenberg AM, Penner R, Kinet JP (2002). "TRPM4 is a Ca2+-activated nonselective cation channel mediating cell membrane depolarization". Cell. 109 (3): 397–407. doi:10.1016/S0092-8674(02)00719-5. PMID 12015988. S2CID 14411824.
• Launay P, Cheng H, Srivatsan S, Penner R, Fleig A, Kinet JP (2004). "TRPM4 regulates calcium oscillations after T cell activation". Science. 306 (5700): 1374–1377. Bibcode:2004Sci...306.1374L. doi:10.1126/science.1098845. PMID 15550671. S2CID 16459097.
• Vennekens R, Nilius B (2007). "Insights into TRPM4 function, regulation and physiological role". Transient Receptor Potential (TRP) Channels. Handbook of Experimental Pharmacology. Vol. 179. pp. 269–85. doi:10.1007/978-3-540-34891-7_16. ISBN 978-3-540-34889-4. PMID 17217063.
• Vennekens R, Olausson J, Meissner M, Bloch W, Mathar I, Philipp SE, Schmitz F, Weissgerber P, Nilius B, Flockerzi V, Freichel M (2007). "Increased IgE-dependent mast cell activation and anaphylactic responses in mice lacking the calcium-activated nonselective cation channel TRPM4" (PDF). Nat Immunol. 8 (3): 312–320. doi:10.1038/ni1441. PMID 17293867. S2CID 29303898.
• Barbet G, Demion M, Moura IC, Serafini N, Léger T, Vrtovsnik F, Monteiro RC, Guinamard R, Kinet JP, Launay P (2008). "The calcium-activated nonselective cation channel TRPM4 is essential for the migration but not the maturation of dendritic cells". Nat Immunol. 9 (10): 1148–56. doi:10.1038/ni.1648. PMC 2956271. PMID 18758465.

External links

• TRPM4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.