TP-13

TP-13
Identifiers
	IUPAC name 7-Cyclobutyl-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-phenyl-1,2,4-triazolo[4,3-b] pyridazine;
CAS Number	202930-12-9;
PubChem CID	9799023;
ChemSpider	7974788;
UNII	DKP4YGH6WN;
Chemical and physical data
Formula	C19H19N7O
Molar mass	361.409 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C5CCC5c3cc2nnc(-c4ccccc4)n2nc3OCc1ncnn1C;
	InChI InChI=1S/C19H19N7O/c1-25-17(20-12-21-25)11-27-19-15(13-8-5-9-13)10-16-22-23-18(26(16)24-19)14-6-3-2-4-7-14/h2-4,6-7,10,12-13H,5,8-9,11H2,1H3; Key:VACJUKKURQMWHE-UHFFFAOYSA-N;
	(verify)

TP-13 is an anxiolytic drug with a novel chemical structure, which is used in scientific research. It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic. It is a subtype-selective partial agonist at GABA_A receptors, binding selectively to GABA_A receptor complexes bearing α2 and α3 subunits.^[1] It has modest anticonvulsant activity although less than that of diazepam,^[2] and its main effect is likely to be selective anxiolytic action, as seen with other related α2/3-preferring agonists such as L-838,417.

References

^ McCabe C, Shaw D, Atack JR, Street LJ, Wafford KA, Dawson GR, et al. (February 2004). "Subtype-selective GABAergic drugs facilitate extinction of mouse operant behaviour". Neuropharmacology. 46 (2): 171–8. doi:10.1016/j.neuropharm.2003.09.004. PMID 14680756. S2CID 38218522.
^ Fradley RL, Guscott MR, Bull S, Hallett DJ, Goodacre SC, Wafford KA, et al. (June 2007). "Differential contribution of GABA(A) receptor subtypes to the anticonvulsant efficacy of benzodiazepine site ligands". Journal of Psychopharmacology. 21 (4): 384–91. doi:10.1177/0269881106067255. PMID 17092983. S2CID 34355306.

This article about an anxiolytic is a stub. You can help Wikipedia by expanding it.

[1] McCabe C, Shaw D, Atack JR, Street LJ, Wafford KA, Dawson GR, et al. (February 2004). "Subtype-selective GABAergic drugs facilitate extinction of mouse operant behaviour". Neuropharmacology. 46 (2): 171–8. doi:10.1016/j.neuropharm.2003.09.004. PMID 14680756. S2CID 38218522.

[2] Fradley RL, Guscott MR, Bull S, Hallett DJ, Goodacre SC, Wafford KA, et al. (June 2007). "Differential contribution of GABA(A) receptor subtypes to the anticonvulsant efficacy of benzodiazepine site ligands". Journal of Psychopharmacology. 21 (4): 384–91. doi:10.1177/0269881106067255. PMID 17092983. S2CID 34355306.

[1]

[2]

Identifiers


IUPAC name 7-Cyclobutyl-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-phenyl-1,2,4-triazolo[4,3-b] pyridazine
CAS Number	202930-12-9
PubChem CID	9799023
ChemSpider	7974788
UNII	DKP4YGH6WN
Chemical and physical data
Formula	C₁₉H₁₉N₇O
Molar mass	361.409 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C5CCC5c3cc2nnc(-c4ccccc4)n2nc3OCc1ncnn1C
InChI InChI=1S/C19H19N7O/c1-25-17(20-12-21-25)11-27-19-15(13-8-5-9-13)10-16-22-23-18(26(16)24-19)14-6-3-2-4-7-14/h2-4,6-7,10,12-13H,5,8-9,11H2,1H3 Key:VACJUKKURQMWHE-UHFFFAOYSA-N
(verify)