CREB regulated transcription coactivator 2 , also known as CRTC2 , is a protein which in humans is encoded by the CRTC2 gene .[ 5] [ 6] [ 7]
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^ Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham JM, et al. (October 2003). "Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells" . Proceedings of the National Academy of Sciences of the United States of America . 100 (21): 12147–52. doi :10.1073/pnas.1932773100 . PMC 218727 . PMID 14506290 .
^ Conkright MD, Canettieri G, Screaton R, Guzman E, Miraglia L, Hogenesch JB, Montminy M (August 2003). "TORCs: transducers of regulated CREB activity" . Molecular Cell . 12 (2): 413–23. doi :10.1016/j.molcel.2003.08.013 . PMID 14536081 .
^ Cheng A, Saltiel AR (March 2006). "More TORC for the gluconeogenic engine". BioEssays . 28 (3): 231–4. CiteSeerX 10.1.1.604.5745 . doi :10.1002/bies.20375 . PMID 16479585 .
^ Rodón L, Svensson RU, Wiater E, Chun MG, Tsai WW, Eichner LJ, et al. (July 2019). "The CREB coactivator CRTC2 promotes oncogenesis in LKB1-mutant non-small cell lung cancer" . Science Advances . 5 (7): eaaw6455. Bibcode :2019SciA....5.6455R . doi :10.1126/sciadv.aaw6455 . PMC 6656544 . PMID 31355336 .
^ a b Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S, et al. (October 2004). "The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector" . Cell . 119 (1): 61–74. doi :10.1016/j.cell.2004.09.015 . PMID 15454081 . S2CID 18616459 .
^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry" . Molecular Systems Biology . 3 (1): 89. doi :10.1038/msb4100134 . PMC 1847948 . PMID 17353931 .
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Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham JM, et al. (October 2003). "Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells" . Proceedings of the National Academy of Sciences of the United States of America . 100 (21): 12147–52. doi :10.1073/pnas.1932773100 . PMC 218727 . PMID 14506290 .
Conkright MD, Canettieri G, Screaton R, Guzman E, Miraglia L, Hogenesch JB, Montminy M (August 2003). "TORCs: transducers of regulated CREB activity" . Molecular Cell . 12 (2): 413–23. doi :10.1016/j.molcel.2003.08.013 . PMID 14536081 .
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Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S, et al. (October 2004). "The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector" . Cell . 119 (1): 61–74. doi :10.1016/j.cell.2004.09.015 . PMID 15454081 . S2CID 18616459 .
Al-Hakim AK, Göransson O, Deak M, Toth R, Campbell DG, Morrice NA, et al. (December 2005). "14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK". Journal of Cell Science . 118 (Pt 23): 5661–73. doi :10.1242/jcs.02670 . PMID 16306228 . S2CID 17404931 .
Siu YT, Chin KT, Siu KL, Yee Wai Choy E, Jeang KT, Jin DY (July 2006). "TORC1 and TORC2 coactivators are required for tax activation of the human T-cell leukemia virus type 1 long terminal repeats" . Journal of Virology . 80 (14): 7052–9. doi :10.1128/JVI.00103-06 . PMC 1489057 . PMID 16809310 .
Wu Z, Huang X, Feng Y, Handschin C, Feng Y, Gullicksen PS, et al. (September 2006). "Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells" . Proceedings of the National Academy of Sciences of the United States of America . 103 (39): 14379–84. Bibcode :2006PNAS..10314379W . doi :10.1073/pnas.0606714103 . PMC 1569674 . PMID 16980408 .
Yang Q, Inoki K, Ikenoue T, Guan KL (October 2006). "Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity" . Genes & Development . 20 (20): 2820–32. doi :10.1101/gad.1461206 . PMC 1619946 . PMID 17043309 .
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry" . Molecular Systems Biology . 3 (1): 89. doi :10.1038/msb4100134 . PMC 1847948 . PMID 17353931 .
Ravnskjaer K, Kester H, Liu Y, Zhang X, Lee D, Yates JR, Montminy M (June 2007). "Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression" . The EMBO Journal . 26 (12): 2880–9. doi :10.1038/sj.emboj.7601715 . PMC 1894761 . PMID 17476304 .
Kuraishy AI, French SW, Sherman M, Herling M, Jones D, Wall R, Teitell MA (June 2007). "TORC2 regulates germinal center repression of the TCL1 oncoprotein to promote B cell development and inhibit transformation" . Proceedings of the National Academy of Sciences of the United States of America . 104 (24): 10175–80. Bibcode :2007PNAS..10410175K . doi :10.1073/pnas.0704170104 . PMC 1891214 . PMID 17548807 .