TEGT

Bax inhibitor 1 is a protein that in humans is encoded by the TMBIM6 gene.

TMBIM6
Identifiers
Aliases	TMBIM6, BAXI1, BI-1, TEGT, transmembrane BAX inhibitor motif containing 6
External IDs	OMIM: 600748; MGI: 99682; HomoloGene: 2419; GeneCards: TMBIM6; OMA:TMBIM6 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12q13.12 Start 49,707,725 bp End 49,764,934 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15 F1|15 56.13 cM Start 99,290,763 bp End 99,307,930 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans renal medulla parotid gland right testis left testis ventricular zone gallbladder mucosa of ileum rectum right adrenal cortex Top expressed in lacrimal gland vestibular membrane of cochlear duct human kidney submandibular gland olfactory epithelium granulocyte epithelium of stomach parotid gland jejunum intestinal villus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function endoribonuclease inhibitor activity protein binding enzyme binding ubiquitin protein ligase binding Cellular component cytoplasm integral component of membrane endoplasmic reticulum membrane membrane mitochondrial membranes integral component of plasma membrane endoplasmic reticulum nucleus Biological process negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway negative regulation of endoribonuclease activity negative regulation of apoptotic signaling pathway negative regulation of apoptotic process negative regulation of protein binding endoplasmic reticulum calcium ion homeostasis response to endoplasmic reticulum stress autophagy response to unfolded protein intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress response to L-glutamate negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway apoptotic process negative regulation of calcium ion transport into cytosol negative regulation of RNA splicing Unfolded Protein Response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7009 110213 Ensembl ENSG00000139644 ENSMUSG00000023010 UniProt P55061 Q9D2C7 RefSeq (mRNA) NM_001098576 NM_003217 NM_001171034 NM_001171035 NM_001171036 NM_026669 RefSeq (protein) NP_001092046 NP_003208 NP_001164505 NP_001164506 NP_001164507 NP_080945 Location (UCSC) Chr 12: 49.71 – 49.76 Mb Chr 15: 99.29 – 99.31 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Cowling RT, Birnboim HC (1999). "Preliminary characterization of the protein encoded by human testis-enhanced gene transcript (TEGT)". Mol. Membr. Biol. 15 (4): 177–87. doi:10.3109/09687689709044319. PMID 10087504.
• Jean JC, Oakes SM, Joyce-Brady M (1999). "The Bax inhibitor-1 gene is differentially regulated in adult testis and developing lung by two alternative TATA-less promoters". Genomics. 57 (2): 201–8. doi:10.1006/geno.1999.5761. PMID 10198159.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Grzmil M, Thelen P, Hemmerlein B, et al. (2003). "Bax inhibitor-1 is overexpressed in prostate cancer and its specific down-regulation by RNA interference leads to cell death in human prostate carcinoma cells". Am. J. Pathol. 163 (2): 543–52. doi:10.1016/S0002-9440(10)63682-6. PMC 1868227. PMID 12875974.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Tanaka R, Ishiyama T, Uchihara T, et al. (2006). "Expression of the Bax inhibitor-1 gene in pulmonary adenocarcinoma". Cancer. 106 (3): 648–53. doi:10.1002/cncr.21639. PMID 16353209. S2CID 1629852.
• Lee GH, Kim HK, Chae SW, et al. (2007). "Bax inhibitor-1 regulates endoplasmic reticulum stress-associated reactive oxygen species and heme oxygenase-1 expression". J. Biol. Chem. 282 (30): 21618–28. doi:10.1074/jbc.M700053200. PMID 17526500.