Transcription factor 7-like 1, also known as TCF7L1, is a human gene.[5]

TCF7L1
Identifiers
AliasesTCF7L1, TCF-3, TCF3, transcription factor 7 like 1
External IDsOMIM: 604652; MGI: 1202876; HomoloGene: 7563; GeneCards: TCF7L1; OMA:TCF7L1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_031283

NM_001079822
NM_009332

RefSeq (protein)

NP_112573

NP_001073290
NP_033358

Location (UCSC)Chr 2: 85.13 – 85.31 MbChr 6: 72.6 – 72.77 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the transforming growth factor beta signaling pathway. The encoded protein contains a high mobility group-box DNA binding domain and participates in the regulation of cell cycle genes and cellular senescence.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000152284Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000055799Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "TCF7L1 transcription factor 7 like 1 [ Homo sapiens (human) ]". Retrieved 2021-05-29.

Further reading

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