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Sulfiram (INN) or monosulfiram, trade name Tetmosol, is an ectoparasiticide used in the treatment and prevention of scabies.[1] It is usually sold as a solution or medicated soap, sometimes in combination with benzyl benzoate.

Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
ATCvet code
Pharmacokinetic data
BioavailabilityVery low
ExcretionRenal, unchanged
CAS Number
PubChem CID
CompTox Dashboard (EPA)
ECHA InfoCard100.002.171 Edit this at Wikidata
Chemical and physical data
Molar mass264.47 g·mol−1 g·mol−1

Sulfiram is now rarely used, but, as of 2015, is still available in Brazil, India, and South Africa (as monotherapy).[1]

Adverse effectsEdit

Dizziness, headache, fatigue and erythematous rash may occur.[2] A single case of toxic epidermal necrolysis was reported in 1968.[3]

Sulfiram is structurally related to disulfiram (Antabuse), and readily converts to disulfiram when exposed to light. Like disulfiram, it can produce an unpleasant reaction when consumed with alcohol.[1][4]


  1. ^ a b c Sweetman, Sean C., ed. (2009). "Pesticides and repellents". Martindale: the complete drug reference (36th ed.). London: Pharmaceutical Press. p. 2050. ISBN 978-0-85369-840-1.
  2. ^ [No authors listed] (2009). "Sarfiram - Bula". Bulário de Remédios Comerciais (in Portuguese). MedicinaNET. Retrieved 2010-08-11.
  3. ^ Copeman PW (March 1968). "Toxic epidermal necrolysis caused by skin hypersensitivity to monosulfiram". British Medical Journal. 1 (5592): 623–4. doi:10.1136/bmj.1.5592.623. PMC 1985336. PMID 5637574.
  4. ^ Mays DC, Nelson AN, Benson LM, Johnson KL, Naylor S, Lipsky JJ (November 1994). "Photolysis of sulfiram: a mechanism for its disulfiram-like reaction". Biochemical Pharmacology. 48 (10): 1917–25. doi:10.1016/0006-2952(94)90590-8. PMID 7986203.

External linksEdit