Striated muscle tissue
Striated muscle tissue is a muscle tissue that features repeating functional units called sarcomeres. The presence of sarcomeres manifests as a series of bands visible along the muscle fibers, which is responsible for the striated appearance observed in microscopic images of this tissue. There are two types of striated muscles:
|Striated muscle tissue|
|Latin||textus muscularis striatus|
Skeletal muscle includes skeletal muscle fibers, blood vessels, nerve fibers, and connective tissue. Skeletal muscle is wrapped in epimysium, allowing structural integrity of the muscle despite contractions. The perimysium organizes the muscle fibers, which are encased in collagen and endomysium, into fascicles. Each muscle fiber contains sarcolemma, sarcoplasm, and sarcoplasmic reticulum. The functional unit of a muscle fiber is called a sarcomere. Each myofiber is composed of actin and myosin myofibrils repeated as a sarcomere.
Based on their contractile and metabolic phenotypes, skeletal muscle can be classified as slow-oxidative (Type I) or fast-oxidative (Type II).
Cardiac muscle lies in between the epicardium and the endocardium in the heart. Cardiac muscle fibers generally only contain one nucleus, located in the central region. They contain many mitochondria and myoglobin. Unlike skeletal muscle, cardiac muscle cells are unicellular. These cells are connected to each other by intercalated disks, which contain gap junctions and desmosomes.
Differences between striated and smooth muscleEdit
The main difference between striated muscle tissue and smooth muscle tissue is that striated muscle tissue features sarcomeres while smooth muscle tissue does not. All striated muscles are attached to some component of the skeleton, unlike smooth muscle, which composes hollow organs such as the intestines or blood vessels. The fibres of striated muscle have a cylindrical shape with blunt ends, whereas those in smooth muscle can be described as being spindle-like with tapered ends. Two other characteristics that differentiate striated muscle from smooth muscle are that the former has more mitochondria and contains cells that are multinucleated.
The main function of striated muscle tissue is to create force and contract. These contractions will either pump blood throughout the body (cardiac muscle) or powers breathing, movement or posture (skeletal muscle).
Contractions in cardiac muscle tissue are due to pacemaker cells. These cells respond to signals from the autonomic nervous system to either increase or decrease the heart rate. Pacemaker cells have autorhythmicity. The set intervals at which they depolarize to threshold and fire action potentials is what determines the heart rate. Because of the gap junctions, the pacemaker cells transfer the depolarization to other cardiac muscle fibers, in order to contract in unison.
Signals from motor neurons cause myofibers to depolarize and therefore release calcium ions from the sarcoplasmic reticulum. The calcium drives the movement of myosin and actin filaments. The sarcomere then shortend which causes the muscle to contract. In the skeletal muscles connected to tendons that pull on bones, the mysia fuses to the periosteum that coats the bone. Contraction of the muscle will transfer to the mysia, then the tendon and the periosteum before causing the bone to move. The mysia also may bind to an aponeurosis or to fascia.
Adult humans cannot regenerate cardiac muscle tissue after an injury, which can lead to scarring and thus heart failure. Mammals have the ability to complete small amounts of cardiac regeneration during development. Vertebrates can regenerate cardiac muscle tissue throughout their entire life span.
Skeletal muscle is able to regenerate far better than cardiac muscle due to satellite cells, which are dormant in all healthy skeletal muscle tissue. There are three phases to the regeneration process. These phases include the inflammatory response, the activation, differentiation, and fusion of satellite cells, and the maturation and remodeling of newly formed myofibrils. This process begins with the necrosis of damaged muscle fibers, which in turn induces the inflammatory response. Macrophages induce phagocytosis of the cell debris. They will eventually secrete anti-inflammatory cytokines, which results in the termination of inflammation. These macrophages can also facilitate the proliferation and differentiation of satellite cells. The satellite cells re-enter the cell cycle to multiply. They then leave the cell cycle to self-renew or differentiate as myoblasts.
- Sarcopenia (loss of skeletal muscle mass associated with aging)
- Polymyositis (chronic inflammation)
- Dermatomyositis (chronic inflammation with skin rash)
- Inclusion body myositis (common age-related inflammatory disease)
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