Streptomyces cattleya is a Gram-positive bacterium which makes cephamycin,[1] penicillin and thienamycin.[2][3] The bacterium expresses a fluorinase enzyme,[4] and the organism has been used to understand the biosynthesis of fluoroacetate and the antibacterial 4-fluoro-L-threonine.[5][6] The γ-Glu-βes pathway to biosynthesis of non-traditional amino acids β-ethynylserine (βes) and L-propargylglycine (Pra) was first characterized in this species.[7]
| Streptomyces cattleya | |
|---|---|
Scientific classification 
| |
| Domain: | Bacteria |
| Phylum: | Actinomycetota |
| Class: | Actinomycetia |
| Order: | Streptomycetales |
| Family: | Streptomycetaceae |
| Genus: | Streptomyces |
| Species: | S. cattleya
|
| Binomial name | |
| Streptomyces cattleya Noble et al. 1978
| |
The genome, which was sequenced in 2011, contains one chromosome with 6,283,062 base pairs and one megaplasmid with 1,809,491 bp, with an overall guanine-cytosine content of 73%.[8]
References edit
- ^ Bodner, MJ; Li, R; Phelan, RM; Freeman, MF; Moshos, KA; Lloyd, EP; Townsend, CA (Sep 19, 2011). "Definition of the common and divergent steps in carbapenem β-lactam antibiotic biosynthesis". ChemBioChem. 12 (14): 2159–65. doi:10.1002/cbic.201100366. PMC 3281309. PMID 21913298.
- ^ Kahan, JS; Kahan, FM; Goegelman, R; Currie, SA; Jackson, M; Stapley, EO; Miller, TW; Miller, AK; Hendlin, D; Mochales, S; Hernandez, S; Woodruff, HB; Birnbaum, J (Jan 1979). "Thienamycin, a new beta-lactam antibiotic. I. Discovery, taxonomy, isolation and physical properties". The Journal of Antibiotics. 32 (1): 1–12. doi:10.7164/antibiotics.32.1. PMID 761989.
- ^ Kahan JS, Kahan FM, Goegelman R, et al. (1979). "Thienamycin, a new beta-lactam antibiotic. I. Discovery, taxonomy, isolation and physical properties". J. Antibiot. 32 (1): 1–12. doi:10.7164/antibiotics.32.1. PMID 761989.
- ^ O'Hagan, David; Schaffrath, Christoph; Cobb, Steven L.; Hamilton, John T. G.; Murphy, Cormac D. (March 2002). "Biochemistry: Biosynthesis of an organofluorine molecule". Nature. 416 (6878): 279. Bibcode:2002Natur.416..279O. doi:10.1038/416279a. PMID 11907567. S2CID 4415511.
- ^ Zhao, C; Li, P; Deng, Z; Ou, HY; McGlinchey, RP; O'Hagan, D (Oct 2012). "Insights into fluorometabolite biosynthesis in Streptomyces cattleya DSM46488 through genome sequence and knockout mutants". Bioorganic Chemistry. 44: 1–7. doi:10.1016/j.bioorg.2012.06.002. PMID 22858315.
- ^ Reid, KA; Hamilton, JT; Bowden, RD; O'Hagan, D; Dasaradhi, L; Amin, MR; Harper, DB (Jun 1995). "Biosynthesis of fluorinated secondary metabolites by Streptomyces cattleya". Microbiology. 141 (6): 1385–93. doi:10.1099/13500872-141-6-1385. PMID 7670640.
- ^ Kuehnel, Karin (May 2019). "A bacterial treasure trove". Nature Methods (Paper). 16 (5): 360. doi:10.1038/s41592-019-0411-1. PMID 31040424.(subscription required)
- ^ Barbe, V; Bouzon, M; Mangenot, S; Badet, B; Poulain, J; Segurens, B; Vallenet, D; Marlière, P; Weissenbach, J (Sep 2011). "Complete genome sequence of Streptomyces cattleya NRRL 8057, a producer of antibiotics and fluorometabolites". Journal of Bacteriology. 193 (18): 5055–6. doi:10.1128/JB.05583-11. PMC 3165681. PMID 21868806.
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