Squalene—-hopanol cyclase

(Redirected from Squalene---hopanol cyclase)

Squalene—hopanol cyclase (EC 4.2.1.129, squalene—hopene cyclase) is an enzyme with systematic name hopan-22-ol hydro-lyase.[1][2] This enzyme catalyses the following chemical reaction

Squalene—hopanol cyclase
Identifiers
EC no.4.2.1.129
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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PMCarticles
PubMedarticles
NCBIproteins
hopan-22-ol squalene + H2O

The enzyme produces the cyclization products hopene and hopanol.

References

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  1. ^ Hoshino T, Nakano S, Kondo T, Sato T, Miyoshi A (May 2004). "Squalene-hopene cyclase: final deprotonation reaction, conformational analysis for the cyclization of (3R,S)-2,3-oxidosqualene and further evidence for the requirement of an isopropylidene moiety both for initiation of the polycyclization cascade and for the formation of the 5-membered E-ring". Organic & Biomolecular Chemistry. 2 (10): 1456–70. doi:10.1039/b401172d. PMID 15136801.
  2. ^ Sato T, Kouda M, Hoshino T (March 2004). "Site-directed mutagenesis experiments on the putative deprotonation site of squalene-hopene cyclase from Alicyclobacillus acidocaldarius". Bioscience, Biotechnology, and Biochemistry. 68 (3): 728–38. doi:10.1271/bbb.68.728. PMID 15056909.
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