Spruce Run may refer to:
- Spruce Run (Delaware County, Ohio)
- Spruce Run (Buffalo Creek tributary), in Union County, Pennsylvania
- Spruce Run (Little Fishing Creek tributary), in Columbia County, Pennsylvania
- Spruce Run (Raritan River tributary), in Hunterdon County, New Jersey
- Spruce Run, New Jersey, in Hunterdon County, New Jersey
- Spruce Run Recreation Area, in Hunterdon County, New Jersey
This disambiguation page lists articles about distinct geographical locations with the same name.
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