Sodium aurothiosulfate

Sodium aurothiosulfate, or sanocrysin, is the inorganic compound with the formula Na3Au(S2O3)2·2H2O. This salt contains an anionic coordination complex of gold(I) bound to two thiosulfate ligands. It is colorless.[1][2]

Sodium aurothiosulfate
SodiumAurothiosulfate.svg
Sodium-gold(I)-thiosulfate-dihydrate-unit-cell-3D-balls.png
Clinical data
Routes of
administration
Intramuscular injection
ATC code
Identifiers
  • Sodium bis(thiosulphate) aurate(I), dihydrate
CAS Number
PubChem CID
CompTox Dashboard (EPA)
Chemical and physical data
FormulaAuNa3O6S4
Molar mass332.08452 g/mol g·mol−1
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Potential applicationsEdit

Like several other gold compounds, this species is used as an antirheumatic.[3] The first placebo-controlled trial was probably conducted in 1931, when sanocrysin was compared with distilled water for the treatment of tuberculosis.[4]

Aurothiosulfate complexes have been discussed in the context of the extraction of gold from its ores. The general approach would employ sodium or ammonium thiosulfate in place of cyanide salts as lixiviants.[5][6]

ReferencesEdit

  1. ^ Baggio RF, Baggio S (1973). "Crystal and molecular structure of trisodium dithiosulphate aurate(I), dihydrate, Na3[Au(S2O3)2],2H2O". Journal of Inorganic and Nuclear Chemistry. 35 (9): 3191–3200. doi:10.1016/0022-1902(73)80019-3.
  2. ^ Tobön-Zapata G, Etcheverry SB, Baran EJ (1997). "Vibrational spectrum of Sanocrysin". Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 53 (2): 183–188. Bibcode:1997AcSpA..53..183T. doi:10.1016/S1386-1425(97)83024-7.
  3. ^ Shaw III CF (September 1999). "Gold-based therapeutic agents". Chemical Reviews. 99 (9): 2589–600. doi:10.1021/cr980431o. PMID 11749494.
  4. ^ Emanuel EJ, Crouch RA, Arras JD, Moreno JD, Grady C, eds. (2003). Ethical and regulatory aspects of clinical research: readings and commentary. Johns Hopkins University Press. p. 140. ISBN 978-0801878138.
  5. ^ Aylmore MG, Muir DM (2001). "Thiosulfate Leaching of Gold - a Review". Minerals Engineering. 14 (2): 135–174. doi:10.1016/s0892-6875(00)00172-2.
  6. ^ Barbera, J. J.; Metzger, A.; Wolf, M. "Sulfites, Thiosulfates, and Dithionites". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007.a25_477.{{cite encyclopedia}}: CS1 maint: uses authors parameter (link)

Source of Chemical Formula: http://medical.merriam-webster.com/medical/gold%20sodium%20thiomalate