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Signature in the Cell: DNA and the Evidence for Intelligent Design is a 2009 book about intelligent design by philosopher and intelligent design advocate Stephen C. Meyer. The book was well received by some within the conservative, intelligent design and evangelical communities, but several other reviewers were critical and wrote that Meyer's claims are incorrect.

Signature in the Cell: DNA and the Evidence for Intelligent Design
Signature in the Cell.JPG
Cover of the first edition
AuthorStephen C. Meyer
CountryUnited States
SubjectIntelligent design
Publication date
June 23, 2009
Media typePrint (Hardcover and Paperback)
Preceded byDarwinism, Design and Public Education 



According to Meyer, historical sciences seek to establish past causes of events using three criteria: (1) that a proposed cause was present, (2) that independent evidence establishes that the proposed cause can indeed produce that event, and (3) that there is an absence of evidence of other possible causes. In his view, the first form of life would have been a functioning, self-replicating, and protein-synthesizing system of DNA and proteins, and as such an information-rich system. Meyer believes that chemical evolution, chance, and chemical necessity have not been proven capable of producing information-rich systems, and that intelligent design is therefore the best explanation for the emergence of life on this planet. He argues that definitions of science that would preclude intelligent design from being a science also preclude many other fields, already established as science, from being science. Meyer believes the designing mind is the God described by the Christian religion. He acknowledges that this may affect the motivations behind his theory.[1]


The book has been well received by some within the conservative, intelligent design and evangelical communities.[2][3][4][5] It was not reviewed by scientific journals or popular science magazines.[6]

Philosopher Thomas Nagel submitted the book to the "2009 Books of the Year" supplement for The Times, writing "Signature in the Cell... is a detailed account of the problem of how life came into existence from lifeless matter – something that had to happen before the process of biological evolution could begin... Meyer is a Christian, but atheists, and theists who believe God never intervenes in the natural world, will be instructed by his careful presentation of this fiendishly difficult problem."[7]

Stephen Fletcher, chemist at Loughborough University, responded in The Times Literary Supplement that Nagel was "promot[ing] the book to the rest of us using statements that are factually incorrect."[8] Fletcher explained that, "Natural selection is in fact a chemical process as well as a biological process, and it was operating for about half a billion years before the earliest cellular life forms appear in the fossil record."[8] In another publication, Fletcher wrote that "I am afraid that reality has overtaken Meyer’s book and its flawed reasoning" in pointing out scientific problems with Meyer's work by citing how RNA "survived and evolved into our own human protein-making factory, and continues to make our fingers and toes."[9]

Darrel Falk, co-president of the BioLogos Foundation and a biology professor at Point Loma Nazarene University, reviewed the book and used it as an example of why he does not support the intelligent design movement.[10] Falk wrote that several of Meyer's claims, such as "no RNA molecule had ever been evolved in a test tube which could do more than join two building blocks together" and "the two different conditions for making two of the key building blocks that characterize an RNA molecule are incompatible", were proven wrong soon after the publication of Meyer's book.[10] Falk was critical of Meyer's declaration of scientists, such as Michael Lynch, being wrong without Meyer conducting any experiments to falsify the established work in the field.[10] Falk wrote, "the book is supposed to be a science book and the ID movement is purported to be primarily a scientific movement—not primarily a philosophical, religious, or even popular movement."[10]

Falk concluded, "If the object of the book is to show that the Intelligent Design movement is a scientific movement, it has not succeeded. In fact, what it has succeeded in showing is that it is a popular movement grounded primarily in the hopes and dreams of those in philosophy, in religion, and especially those in the general public."[10] In 2010 the BioLogos Foundation published Meyer's response to Falk. The response criticizes Falk's characterization of Meyer's credentials as well as the lack of any evidence from Falk that the premise of his book is faulty.[11]

The American Scientific Affiliation, a Christian organization of scientists and others, published a detailed analysis of the book's assertions by their executive director, physicist Randall Isaac. He concluded, "It is laudable that Meyer takes the step to explore predictions that ID would make. Predictions that are testable are a vital part of the scientific process. But just making a prediction isn’t sufficient to indicate viable science. Astrologers and tasseologists can also make predictions and sometimes they may be right. Predictions must also be based on causal factors that are understood independently to exist and whose adequacy can be independently verified. The predictions must clearly differentiate between competing hypotheses. It is unfortunate that this set of dozen predictions is very weak on all counts. It is unlikely to make any difference in the debate. These tend not to be definitive in terms of distinguishing between ID or non ID and will only extend the discussion."[5][6]

Steve Matheson, a developmental biologist at Calvin College (an institution of the Christian Reformed Church), wrote an analysis critical of the book.[6][12] In a post on The Panda's Thumb, Richard Hoppe concluded that the book failed to make a strong case for ID.[6]

The Discovery Institute published a collection of responses to critics edited by David Klinghoffer.[13]


  1. ^ Meyer, Stephen (2009). Signature in the Cell: DNA and the Evidence for Intelligent Design. New York: HarperCollins.
  2. ^ Peterson, Dan (September 2009). "Blown Away". American Spectator.
  3. ^ Peterson, Ken (6 October 2009). "Signature in the Cell". Spectrum.
  4. ^ Times Review, The Times.
  5. ^ a b Isaac, Randy. "Signature in the Cell". ASA Book Discussion. American Scientific Affiliation (ASA). Retrieved 1 May 2014.
  6. ^ a b c d Hoppe, Richard B. (24 April 2010). "Two analyses of Meyer's 'Signature in the Cell'". The Panda's Thumb. Retrieved 1 May 2014.
  7. ^ "2009 Books of the Year". The Times.
  8. ^ a b Fletcher, Stephen (2 December 2009). "TLS Letters 02/12/09". The Times Literary Supplement (letter to the editor). Retrieved 2010-03-28.
  9. ^ Fletcher, Stephen (3 February 2010). "TLS Letters 03/02/10". The Times Literary Supplement (letter to the editor). Retrieved 2010-03-28.
  10. ^ a b c d e Falk, Darrel (28 December 2009). "Science & the Sacred: Signature in the Cell" (blog). BioLogos Foundation. Retrieved 2009-12-28.
  11. ^ "Response to Darrel Falk's Review of 'Signature in the Cell'" (blog). BioLogos Foundation. 28 January 2010.
  12. ^ Matheson, Steve. "Book Reviews". Quintessence of Dust. Retrieved 1 May 2014.
  13. ^ Klinghoffer, David, ed. (2011). Signature of Controversy. Discovery Institute. ISBN 9780979014185.

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