Sigismondo d'Este may refer to:
- Sigismondo d'Este (1433-1507), second son of Niccolò III d'Este and his third wife Ricciarda di Saluzzo
- Sigismondo d'Este (1480-1524), youngest son of Ercole I d'Este, Duke of Ferrara, and Eleanor of Aragon
This disambiguation page lists articles about people with the same name.
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