Shisen may refer to:
- the Chinese Sichuan Province (四川) in Japanese
- Shisen-dō (詩仙堂), a Buddhist temple of the Sōtō Zen sect in Sakyō-ku, Kyoto, Japan
- Shisen-Sho (四川省), a Japanese tile-based game similar to Mahjong solitaire
- Heart Aid Shisen (Japanese: ハートエイド・四川, Chinese: 心系四川), a major fund raising concert held on July 14, 2008, in Tokyo, Japan for the victims of the 2008 Sichuan earthquake