STK35L1 is a protein that in humans is encoded by the STK35 (serine/threonine kinase 35) gene.[5] It is a member of the NKF4 (New Kinase Family 4) Ser/Thr kinases (STK) family and classified in group "Other" in the human kinome. Previously, STK35L1 was named as Clik1 (CLP36 Interacting Kinase 1) based on a study that showed an association of STK35 with CLP36 after overexpression of both proteins in osteosarcoma cells.[6][7] Clik1 gene described by Vallenius et al. code for a protein of 501 amino acids. Later, Goyal et al. found that coding sequence of the STK35 gene is incomplete. The newly identified sequence of the STK35 gene codes for a protein of 534 amino acids with a N-terminal elongation of 133 amino acids. It has been designated as STK35L1.

STK35
Identifiers
AliasesSTK35, serine/threonine kinase 35, CLIK1, STK35L1, Serine/threonine kinase 35
External IDsOMIM: 609370; MGI: 1914583; HomoloGene: 15441; GeneCards: STK35; OMA:STK35 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_080836

NM_001038635
NM_183262

RefSeq (protein)

NP_543026

NP_001033724
NP_899085

Location (UCSC)Chr 20: 2.1 – 2.18 MbChr 2: 129.64 – 129.67 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Functions

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STK35L1 is predominantly found in the nucleus and the nucleolus. Nuclear actin was identified as a novel binding partner of STK35L1.[8] However, it can interact with PDLIM1/CLP-36 in the cytoplasm and localize to actin stress fibers. STK35L1 regulates the expression of CDKN2A and inhibiting G1- to S-phase transition. Depletion of STK35L1 by siRNA impaired endothelial cell migration. STK35L1 may act as a central kinase linking the cell cycle and migration of endothelial cells.

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000125834Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037885Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Serine/threonine kinase 35". Retrieved 2012-02-18.
  6. ^ Vallenius T, Mäkelä TP (May 2002). "Clik1: a novel kinase targeted to actin stress fibers by the CLP-36 PDZ-LIM protein". Journal of Cell Science. 115 (Pt 10): 2067–73. doi:10.1242/jcs.115.10.2067. PMID 11973348.
  7. ^ Goyal P, Behring A, Kumar A, Siess W (2009-09-16). "Identifying and characterizing a novel protein kinase STK35L1 and deciphering its orthologs and close-homologs in vertebrates". PLOS ONE. 4 (9): e6981. Bibcode:2009PLoSO...4.6981G. doi:10.1371/journal.pone.0006981. PMC 2737284. PMID 19756140.
  8. ^ Goyal P, Behring A, Kumar A, Siess W (2011-01-20). "STK35L1 associates with nuclear actin and regulates cell cycle and migration of endothelial cells". PLOS ONE. 6 (1): e16249. Bibcode:2011PLoSO...616249G. doi:10.1371/journal.pone.0016249. PMC 3024402. PMID 21283756.

Further reading

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