William Upham (1792–1853) was a U.S. Senator from Vermont from 1843 to 1853. Senator Upham may also refer to:
- Alonzo S. Upham (1811–1882), New York State Senate
- Charles Wentworth Upham (1802–1875), Massachusetts State Senate
- George B. Upham (1768–1848), New Hampshire State Senate
This disambiguation page lists articles associated with the title Senator Upham.
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