Santiago Rodríguez may refer to:
- Santiago Rodríguez Masagó, Dominican military leader
- Santiago Rodríguez Province, province of the Dominican Republic
- Santiago Luis Polanco Rodríguez (born 1961), Dominican American former drug dealer
- Santiago Rodriguez (pianist), Cuban musician
- Santiago Rodríguez (footballer) (born 2000), Uruguayan footballer
This disambiguation page lists articles associated with the title Santiago Rodríguez.
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