Sant'Onofrio is the Italian name of St. Onuphrius. This name may refer to:
- Sant'Onofrio (Rome), a church in Rome
- Sant'Onofrio, Calabria, a municipality in Italy
- Sant'Onofrio (Campli), a comune (frazioni) in Teramo, Abruzzo, Italy
- Hermitage of Sant'Onofrio, Serramonacesca, Abruzzo
- Sant'Onofrio (Lanciano), a frazione of Chieti
- Hermitage of Sant'Onofrio al Morrone, Sulmona, Abruzzo
- Sant'Onofrio Altarpiece by Luca Signorelli, on display in Duomo, Orvieto
This disambiguation page lists articles associated with the title Sant'Onofrio.
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