San Pablo District may refer to
- Paraguay
- San Pablo District, Paraguay, in San Pedro department
- Peru
- San Pablo District, Bellavista, in Bellavista province, San Martín region
- San Pablo District, Canchis, in Bellavista province, Cusco region
- San Pablo District, Mariscal Ramón Castilla, in Mariscal Ramón Castilla province, Loreto region
- San Pablo District, San Pablo, in San Pablo province, Cajamarca region
- Costa Rica
- San Pablo District, Barva, in Barva Canton, Heredia province
- San Pablo District, León Cortés Castro, in León Cortés Canton, San José province
- San Pablo District, Nandayure, in Nandayure Canton, Guanacaste province
- San Pablo District, San Pablo, Heredia, in San Pablo Canton, Heredia province
- San Pablo District, Turrubares, in Turrubares Canton, San José province