San Isidro District may refer to:
- Peru
- San Isidro District, Lima, a district of the Lima province
- Costa Rica
- San Isidro District, Alajuela, in Alajuela (canton), Alajuela province
- San Isidro District, Atenas, in Atenas (canton), Alajuela province
- San Isidro District, El Guarco, in El Guarco (canton), Cartago province
- San Isidro District, Grecia, in Grecia (canton), Alajuela province
- San Isidro District, León Cortés, in León Cortés (canton), San José province
- San Isidro District, Montes de Oro, in Montes de Oro (canton), Puntarenas province
- San Isidro District, San Isidro, in San Isidro (canton), Heredia province
- San Isidro District, San Ramón, in San Ramón (canton), Alajuela province
- San Isidro, Vázquez de Coronado, in Vázquez de Coronado (canton), San José province
- San Isidro del El General District, in Pérez Zeledón (canton), San José province
This disambiguation page lists articles about distinct geographical locations with the same name.
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