San Francisco River
- For the river in Brazil, see São Francisco River. For the river in Argentina, see San Francisco River (Argentina). In Ecuador, the Río San Francisco is a tributary of the Zamora River in Zamora-Chinchipe province.
The San Francisco River is a 159-mile-long (256 km) river in the southwest United States, the largest tributary of the Upper Gila River. The river originates near Alpine, Arizona and flows into New Mexico before re-entering Arizona and joining the Gila downstream from Clifton, Arizona.