Samuel Guthrie may refer to:
- Samuel Guthrie (politician) (1885–1960), British Columbia CCF MLA
- Samuel Guthrie (physician) (1782–1848), U.S. physician who discovered chloroform
- Samuel Zachary Guthrie, alias Cannonball, a Marvel Comics character who's a member of the New Mutants, X-Men, and Avengers
This disambiguation page lists articles about people with the same name.
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