Small ubiquitin-related modifier 4 is a protein that in humans is encoded by the SUMO4 gene.[3][4]

SUMO4
Identifiers
AliasesSUMO4, IDDM5, SMT3H4, SUMO-4, dJ281H8.4, small ubiquitin-like modifier 4, small ubiquitin like modifier 4
External IDsOMIM: 608829; HomoloGene: 88399; GeneCards: SUMO4; OMA:SUMO4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001002255

n/a

RefSeq (protein)

NP_001002255

n/a

Location (UCSC)Chr 6: 149.4 – 149.4 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Function

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This gene is a member of the SUMO gene family. This family of genes encode small ubiquitin-related modifiers that are attached to proteins and control the target proteins' subcellular localization, stability, or activity. The protein described in this record is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. A specific polymorphism in this SUMO gene, which leads to the M55V substitution, has been associated with type I diabetes. The RefSeq contains this polymorphism.[4]

Interactions

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SUMO4 has been shown to interact with IκBα.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000177688Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Bohren KM, Nadkarni V, Song JH, Gabbay KH, Owerbach D (Jun 2004). "A M55V polymorphism in a novel SUMO gene (SUMO-4) differentially activates heat shock transcription factors and is associated with susceptibility to type I diabetes mellitus". The Journal of Biological Chemistry. 279 (26): 27233–8. doi:10.1074/jbc.M402273200. PMID 15123604.
  4. ^ a b "Entrez Gene: SUMO4 SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae)".
  5. ^ Guo D, Li M, Zhang Y, Yang P, Eckenrode S, Hopkins D, Zheng W, Purohit S, Podolsky RH, Muir A, Wang J, Dong Z, Brusko T, Atkinson M, Pozzilli P, Zeidler A, Raffel LJ, Jacob CO, Park Y, Serrano-Rios M, Larrad MT, Zhang Z, Garchon HJ, Bach JF, Rotter JI, She JX, Wang CY (Aug 2004). "A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes". Nature Genetics. 36 (8): 837–41. doi:10.1038/ng1391. PMID 15247916. S2CID 41123857.

Further reading

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