STOML2

Stomatin-like protein 2 is a protein that in humans is encoded by the STOML2 gene.

STOML2
Identifiers
Aliases	STOML2, SLP-2, HSPC108, stomatin like 2
External IDs	OMIM: 608292; MGI: 1913842; HomoloGene: 8389; GeneCards: STOML2; OMA:STOML2 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) Band 9p13.3 Start 35,099,776 bp End 35,103,195 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 A5 Start 43,027,690 bp End 43,031,710 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart mucosa of transverse colon right adrenal gland right adrenal cortex gastrocnemius muscle left adrenal gland left adrenal cortex left ventricle body of stomach rectum Top expressed in epiblast ventricular zone neural tube embryo adrenal gland embryo proximal tubule limb quadriceps femoris muscle tail of embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cardiolipin binding protein binding GTPase binding signaling receptor binding lipid binding Cellular component cytoplasm membrane mitochondrial intermembrane space plasma membrane T cell receptor complex mitochondrion immunological synapse actin cytoskeleton membrane raft COP9 signalosome extrinsic component of plasma membrane cytoskeleton mitochondrial inner membrane Biological process CD4-positive, alpha-beta T cell activation mitochondrial ATP synthesis coupled proton transport mitochondrion organization cellular calcium ion homeostasis positive regulation of mitochondrial DNA replication mitochondrial protein processing lipid localization protein complex oligomerization stress-induced mitochondrial fusion positive regulation of cardiolipin metabolic process positive regulation of mitochondrial membrane potential T cell receptor signaling pathway interleukin-2 production mitochondrial calcium ion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 30968 66592 Ensembl ENSG00000165283 ENSMUSG00000028455 UniProt Q9UJZ1 Q99JB2 RefSeq (mRNA) NM_013442 NM_001287031 NM_001287032 NM_001287033 NM_023231 RefSeq (protein) NP_001273960 NP_001273961 NP_001273962 NP_038470 NP_075720 Location (UCSC) Chr 9: 35.1 – 35.1 Mb Chr 4: 43.03 – 43.03 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Owczarek CM, Treutlein HR, Portbury KJ, et al. (2001). "A novel member of the STOMATIN/EPB72/mec-2 family, stomatin-like 2 (STOML2), is ubiquitously expressed and localizes to HSA chromosome 9p13.1". Cytogenet. Cell Genet. 92 (3–4): 196–203. doi:10.1159/000056902. PMID 11435687. S2CID 19349691.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
• Guo D, Han J, Adam BL, et al. (2005). "Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochem. Biophys. Res. Commun. 337 (4): 1308–18. doi:10.1016/j.bbrc.2005.09.191. PMID 16236267.
• Zhang L, Ding F, Cao W, et al. (2006). "Stomatin-like protein 2 is overexpressed in cancer and involved in regulating cell growth and cell adhesion in human esophageal squamous cell carcinoma". Clin. Cancer Res. 12 (5): 1639–46. doi:10.1158/1078-0432.CCR-05-1858. PMID 16533792.
• John JP, Anrather D, Pollak A, Lubec G (2006). "Mass spectrometrical verification of stomatin-like protein 2 (SLP-2) primary structure". Proteins. 64 (2): 543–51. doi:10.1002/prot.20987. PMID 16671055. S2CID 24782924.
• Cui Z, Zhang L, Hua Z, et al. (2007). "Stomatin-like protein 2 is overexpressed and related to cell growth in human endometrial adenocarcinoma". Oncol. Rep. 17 (4): 829–33. doi:10.3892/or.17.4.829. PMID 17342323.
• Cao W, Zhang B, Liu Y, et al. (2007). "High-level SLP-2 expression and HER-2/neu protein expression are associated with decreased breast cancer patient survival". Am. J. Clin. Pathol. 128 (3): 430–6. doi:10.1309/C6X54HRB580EP2NQ. PMID 17709317.