STAU2

STAU2
Identifiers
Aliases	STAU2, 39K2, 39K3, staufen double-stranded RNA binding protein 2
External IDs	OMIM: 605920; MGI: 1352508; HomoloGene: 8666; GeneCards: STAU2; OMA:STAU2 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	73,747,708 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	16,590,336 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; prefrontal cortex; ; muscle of thigh; ; gastrocnemius muscle; ; Brodmann area 9; ; right frontal lobe; ; ventricular zone; ; cingulate gyrus; ; anterior cingulate cortex; ; epithelium of colon;
	Top expressed in
	Rostral migratory stream; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; medial vestibular nucleus; ; piriform cortex; ; deep cerebellar nuclei; ; barrel cortex; ; Region I of hippocampus proper; ; facial motor nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	double-stranded RNA binding; protein binding; RNA binding;
Cellular component	cytoplasm; microtubule; nucleolus; endoplasmic reticulum; membrane; nucleus;
Biological process	transport;
	Sources:Amigo / QuickGO
Orthologs
	27067
	29819
	ENSG00000040341
	ENSMUSG00000025920
	Q9NUL3
	Q8CJ67
NM_014393; NM_001164380; NM_001164381; NM_001164382; NM_001164383;
	NM_001164384; NM_001164385
	NM_001111272; NM_025303; NM_001347044; NM_001347045
NP_001157852; NP_001157853; NP_001157854; NP_001157855; NP_001157856;
	NP_001157857; NP_055208
	NP_001104742; NP_001333973; NP_001333974; NP_079579
	Wikidata
View/Edit Human	View/Edit Mouse

Double-stranded RNA-binding protein Staufen homolog 2 is a protein that in humans is encoded by the STAU2 gene.^[5]^[6]

Function

Staufen homolog 2 is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. Staufen homolog 2 shares 48.5% and 59.9% similarity with drosophila and human staufen, respectively. The exact function of Staufen homolog 2 is not known, but since it contains 3 copies of conserved dsRNA binding domain, it could be involved in double-stranded RNA binding events.^[6] Expression of Stau2 was sufficient to increase eye size, suggesting a novel biological role of Stau2 in eye morphogenesis.^[7] Acting as a HIV-1 dependency factor, Staufen-2 promotes HIV-1 proliferation by positively regulating RNA export activity of viral protein Rev ^[8] and recently it was reported that Staufen-2 is incorporated into HIV-1 particles and boost viral infectivity^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000040341 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025920 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Buchner G, Bassi MT, Andolfi G, Ballabio A, Franco B (November 1999). "Identification of a novel homolog of the Drosophila staufen protein in the chromosome 8q13-q21.1 region". Genomics. 62 (1): 113–8. doi:10.1006/geno.1999.6015. PMID 10585778.
^ ^a ^b "Entrez Gene: STAU2 staufen, RNA binding protein, homolog 2 (Drosophila)".
^ Cockburn, Diane M.; Charish, Jason; Tassew, Nardos G.; Eubanks, James; Bremner, Rod; Macchi, Paolo; Monnier, Philippe P. (November 2012). "The double-stranded RNA-binding protein Staufen 2 regulates eye size". Molecular and Cellular Neuroscience. 51 (3–4): 101–111. doi:10.1016/j.mcn.2012.08.008. PMID 22940085. S2CID 5193038.
^ Banerjee, Atoshi; Benjamin, Ronald; Balakrishnan, Kannan; Ghosh, Payel; Banerjee, Sharmistha (2014-02-13). "Human protein Staufen-2 promotes HIV-1 proliferation by positively regulating RNA export activity of viral protein Rev". Retrovirology. 11: 18. doi:10.1186/1742-4690-11-18. ISSN 1742-4690. PMC 4016256. PMID 24520823.
^ Balakrishnan, Kannan; Jaguva Vasudevan, Ananda; Mohareer, Krishnaveni; Luedde, Tom; Münk, Carsten; Banerjee, Sharmistha (2021-12-08). "Encapsidation of Staufen-2 Enhances Infectivity of HIV-1". Viruses. 13 (12): 2459. doi:10.3390/v13122459. ISSN 1999-4915. PMC 8703407. PMID 34960728.

Kiebler MA, DesGroseillers L (January 2000). "Molecular insights into mRNA transport and local translation in the mammalian nervous system". Neuron. 25 (1): 19–28. doi:10.1016/S0896-6273(00)80868-5. PMID 10707969. S2CID 2565210.
Furic L, Maher-Laporte M, DesGroseillers L (February 2008). "A genome-wide approach identifies distinct but overlapping subsets of cellular mRNAs associated with Staufen1- and Staufen2-containing ribonucleoprotein complexes". RNA. 14 (2): 324–35. doi:10.1261/rna.720308. PMC 2212254. PMID 18094122.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Chatel-Chaix L, Clément JF, Martel C, Bériault V, Gatignol A, DesGroseillers L, Mouland AJ (April 2004). "Identification of Staufen in the human immunodeficiency virus type 1 Gag ribonucleoprotein complex and a role in generating infectious viral particles". Molecular and Cellular Biology. 24 (7): 2637–48. doi:10.1128/MCB.24.7.2637-2648.2004. PMC 371130. PMID 15024055.
Duchaîne TF, Hemraj I, Furic L, Deitinghoff A, Kiebler MA, DesGroseillers L (August 2002). "Staufen2 isoforms localize to the somatodendritic domain of neurons and interact with different organelles". Journal of Cell Science. 115 (Pt 16): 3285–95. doi:10.1242/jcs.115.16.3285. PMID 12140260.

This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000040341 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025920 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10585778-5] Buchner G, Bassi MT, Andolfi G, Ballabio A, Franco B (November 1999). "Identification of a novel homolog of the Drosophila staufen protein in the chromosome 8q13-q21.1 region". Genomics. 62 (1): 113–8. doi:10.1006/geno.1999.6015. PMID 10585778.

[entrez-6] "Entrez Gene: STAU2 staufen, RNA binding protein, homolog 2 (Drosophila)".

[7] Cockburn, Diane M.; Charish, Jason; Tassew, Nardos G.; Eubanks, James; Bremner, Rod; Macchi, Paolo; Monnier, Philippe P. (November 2012). "The double-stranded RNA-binding protein Staufen 2 regulates eye size". Molecular and Cellular Neuroscience. 51 (3–4): 101–111. doi:10.1016/j.mcn.2012.08.008. PMID 22940085. S2CID 5193038.

[8] Banerjee, Atoshi; Benjamin, Ronald; Balakrishnan, Kannan; Ghosh, Payel; Banerjee, Sharmistha (2014-02-13). "Human protein Staufen-2 promotes HIV-1 proliferation by positively regulating RNA export activity of viral protein Rev". Retrovirology. 11: 18. doi:10.1186/1742-4690-11-18. ISSN 1742-4690. PMC 4016256. PMID 24520823.

[9] Balakrishnan, Kannan; Jaguva Vasudevan, Ananda; Mohareer, Krishnaveni; Luedde, Tom; Münk, Carsten; Banerjee, Sharmistha (2021-12-08). "Encapsidation of Staufen-2 Enhances Infectivity of HIV-1". Viruses. 13 (12): 2459. doi:10.3390/v13122459. ISSN 1999-4915. PMC 8703407. PMID 34960728.

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STAU2

Function

References

Further reading