Alpha-2,8-sialyltransferase 8B is an enzyme that in humans is encoded by the ST8SIA2 gene.[5][6]

ST8SIA2
Identifiers
AliasesST8SIA2, HsT19690, SIAT8B, ST8SIA-II, STX, ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2, SIAT8-B, ST8SiaII
External IDsOMIM: 602546; MGI: 106020; HomoloGene: 4384; GeneCards: ST8SIA2; OMA:ST8SIA2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006011
NM_001330416

NM_009181

RefSeq (protein)

NP_001317345
NP_006002
NP_006002.1

NP_033207

Location (UCSC)Chr 15: 92.39 – 92.47 MbChr 7: 73.59 – 73.66 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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The protein encoded by this gene is a type II membrane protein that is thought to catalyze the transfer of sialic acid from CMP-sialic acid to N-linked oligosaccharides and glycoproteins. The encoded protein may be found in the Golgi apparatus and may be involved in the production of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). This protein is a member of glycosyltransferase family 29.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000140557Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025789Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Scheidegger EP, Sternberg LR, Roth J, Lowe JB (September 1995). "A human STX cDNA confers polysialic acid expression in mammalian cells". The Journal of Biological Chemistry. 270 (39): 22685–8. doi:10.1074/jbc.270.39.22685. PMID 7559389.
  6. ^ a b "Entrez Gene: ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2".

Further reading

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