Suppressor of tumorigenicity protein 7 is a protein that in humans is encoded by the ST7gene.[5][6][7] ST7 orthologs[8] have been identified in all mammals for which complete genome data are available.
The gene for this product maps to a region on human chromosome 7 identified as an autism-susceptibility locus. Mutation screening of the entire coding region in autistic individuals failed to identify phenotype-specific variants, suggesting that coding mutations for this gene are unlikely to be involved in the etiology of autism. The function of this gene product has not been determined. Transcript variants encoding different isoforms of this protein have been described.[7]
^ abBattle MA, Maher VM, McCormick JJ (June 2003). "ST7 is a novel low-density lipoprotein receptor-related protein (LRP) with a cytoplasmic tail that interacts with proteins related to signal transduction pathways". Biochemistry. 42 (24): 7270–82. doi:10.1021/bi034081y. PMID12809483.
Zenklusen JC, Weitzel JN, Ball HG, Conti CJ (July 1995). "Allelic loss at 7q31.1 in human primary ovarian carcinomas suggests the existence of a tumor suppressor gene". Oncogene. 11 (2): 359–63. PMID7624150.
Zenklusen JC, Thompson JC, Troncoso P, Kagan J, Conti CJ (December 1994). "Loss of heterozygosity in human primary prostate carcinomas: a possible tumor suppressor gene at 7q31.1". Cancer Research. 54 (24): 6370–3. PMID7987830.
Zenklusen JC, Conti CJ, Green ED (April 2001). "Mutational and functional analyses reveal that ST7 is a highly conserved tumor-suppressor gene on human chromosome 7q31". Nature Genetics. 27 (4): 392–8. doi:10.1038/86891. PMID11279520. S2CID2749283.
Vincent JB, Petek E, Thevarkunnel S, Kolozsvari D, Cheung J, Patel M, Scherer SW (September 2002). "The RAY1/ST7 tumor-suppressor locus on chromosome 7q31 represents a complex multi-transcript system". Genomics. 80 (3): 283–94. doi:10.1006/geno.2002.6835. PMID12213198.
Dong SM, Sidransky D (September 2002). "Absence of ST7 gene alterations in human cancer". Clinical Cancer Research. 8 (9): 2939–41. PMID12231539.
Battle MA, Maher VM, McCormick JJ (June 2003). "ST7 is a novel low-density lipoprotein receptor-related protein (LRP) with a cytoplasmic tail that interacts with proteins related to signal transduction pathways". Biochemistry. 42 (24): 7270–82. doi:10.1021/bi034081y. PMID12809483.
Sivasundaram K, Suzuki H, Seto M, Hosokawa Y (2004). "Mutational analysis of the ST7 gene in human myeloid tumor cell lines". Oncology Reports. 10 (6): 1737–9. doi:10.3892/or.10.6.1737. PMID14534688.
