ST6GALNAC1

ST6GALNAC1
Identifiers
Aliases	ST6GALNAC1, HSY11339, SIAT7A, ST6GalNAcI, STYI, ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
External IDs	OMIM: 610138; MGI: 1341826; HomoloGene: 7937; GeneCards: ST6GALNAC1; OMA:ST6GALNAC1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	76,643,786 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	116,666,333 bp
RNA expression pattern
	Top expressed in
	mucosa of sigmoid colon; ; mucosa of ileum; ; rectum; ; nasal epithelium; ; bronchial epithelial cell; ; mucosa of transverse colon; ; olfactory zone of nasal mucosa; ; jejunal mucosa; ; trachea; ; duodenum;
	Top expressed in
	conjunctival fornix; ; corneal stroma; ; lacrimal gland; ; submandibular gland; ; parotid gland; ; Paneth cell; ; muscle of thigh; ; small intestine; ; ileum; ; central gray substance of midbrain;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; sialyltransferase activity; glycosyltransferase activity; alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity;
Cellular component	integral component of membrane; Golgi apparatus; membrane; Golgi membrane;
Biological process	sialylation; protein glycosylation; oligosaccharide biosynthetic process; oligosaccharide metabolic process; protein N-linked glycosylation via asparagine; ganglioside biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	55808
	20445
	ENSG00000070526
	ENSMUSG00000009588
	Q9NSC7
	Q9QZ39
	NM_001289107; NM_018414
	NM_011371
	NP_001276036; NP_060884
	NP_035501
	Wikidata
View/Edit Human	View/Edit Mouse

Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 is an enzyme that in humans is encoded by the ST6GALNAC1 gene.^[5] This enzyme adds a N-acetylneuraminic acid (Neu5Ac, a sialic acid) to an O-linked N-acetylgalactosamine (GalNAc) on a peptide/proteins (also called Tn antigen) with an α2-6 linkage to produce the sialyl-Tn antigen. It has been shown that the enzyme prefers threonine over serine containing GalNAc residues.^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000070526 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000009588 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: ST6GALNAC1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1".
^ Mehta AY, Veeraiah RK, Dutta S, Goth CK, Hanes MS, Gao C, et al. (June 2020). "Parallel Glyco-SPOT Synthesis of Glycopeptide Libraries". Cell Chemical Biology. 27 (9): 1207–1219.e9. doi:10.1016/j.chembiol.2020.06.007. PMC 7556346. PMID 32610041.
^ Yoshimura Y, Denda-Nagai K, Takahashi Y, Nagashima I, Shimizu H, Kishimoto T, et al. (November 2019). "Products of Chemoenzymatic Synthesis Representing MUC1 Tandem Repeat Unit with T-, ST- or STn-antigen Revealed Distinct Specificities of Anti-MUC1 Antibodies". Scientific Reports. 9 (1): 16641. Bibcode:2019NatSR...916641Y. doi:10.1038/s41598-019-53052-1. PMC 6851390. PMID 31719620.

Lee YC, Kaufmann M, Kitazume-Kawaguchi S, Kono M, Takashima S, Kurosawa N, Liu H, Pircher H, Tsuji S (April 1999). "Molecular cloning and functional expression of two members of mouse NeuAcalpha2,3Galbeta1,3GalNAc GalNAcalpha2,6-sialyltransferase family, ST6GalNAc III and IV". The Journal of Biological Chemistry. 274 (17): 11958–67. doi:10.1074/jbc.274.17.11958. PMID 10207017.
Ikehara Y, Kojima N, Kurosawa N, Kudo T, Kono M, Nishihara S, Issiki S, Morozumi K, Itzkowitz S, Tsuda T, Nishimura SI, Tsuji S, Narimatsu H (November 1999). "Cloning and expression of a human gene encoding an N-acetylgalactosamine-alpha2,6-sialyltransferase (ST6GalNAc I): a candidate for synthesis of cancer-associated sialyl-Tn antigens". Glycobiology. 9 (11): 1213–24. doi:10.1093/glycob/9.11.1213. PMID 10536037.
Donadio S, Dubois C, Fichant G, Roybon L, Guillemot JC, Breton C, Ronin C (2004). "Recognition of cell surface acceptors by two human alpha-2,6-sialyltransferases produced in CHO cells". Biochimie. 85 (3–4): 311–21. doi:10.1016/S0300-9084(03)00080-4. PMID 12770770.
Julien S, Krzewinski-Recchi MA, Harduin-Lepers A, Gouyer V, Huet G, Le Bourhis X, Delannoy P (2003). "Expression of sialyl-Tn antigen in breast cancer cells transfected with the human CMP-Neu5Ac: GalNAc alpha2,6-sialyltransferase (ST6GalNac I) cDNA". Glycoconjugate Journal. 18 (11–12): 883–93. doi:10.1023/A:1022200525695. PMID 12820722. S2CID 21051703.
Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (October 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Sewell R, Bäckström M, Dalziel M, Gschmeissner S, Karlsson H, Noll T, Gätgens J, Clausen H, Hansson GC, Burchell J, Taylor-Papadimitriou J (February 2006). "The ST6GalNAc-I sialyltransferase localizes throughout the Golgi and is responsible for the synthesis of the tumor-associated sialyl-Tn O-glycan in human breast cancer". The Journal of Biological Chemistry. 281 (6): 3586–94. doi:10.1074/jbc.M511826200. PMID 16319059.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000070526 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000009588 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: ST6GALNAC1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1".

[6] Mehta AY, Veeraiah RK, Dutta S, Goth CK, Hanes MS, Gao C, et al. (June 2020). "Parallel Glyco-SPOT Synthesis of Glycopeptide Libraries". Cell Chemical Biology. 27 (9): 1207–1219.e9. doi:10.1016/j.chembiol.2020.06.007. PMC 7556346. PMID 32610041.

[7] Yoshimura Y, Denda-Nagai K, Takahashi Y, Nagashima I, Shimizu H, Kishimoto T, et al. (November 2019). "Products of Chemoenzymatic Synthesis Representing MUC1 Tandem Repeat Unit with T-, ST- or STn-antigen Revealed Distinct Specificities of Anti-MUC1 Antibodies". Scientific Reports. 9 (1): 16641. Bibcode:2019NatSR...916641Y. doi:10.1038/s41598-019-53052-1. PMC 6851390. PMID 31719620.

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ST6GALNAC1

See also

References

Further reading