ST3GAL4

CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase is an enzyme that in humans is encoded by the ST3GAL4 gene.

ST3GAL4
Identifiers
Aliases	ST3GAL4, CGS23, NANTA3, SAT3, SIAT4, SIAT4C, ST3GalIV, STZ, ST3 beta-galactoside alpha-2,3-sialyltransferase 4, ST-4, gal-NAc6S, ST3GalA.2
External IDs	OMIM: 104240; MGI: 1316743; HomoloGene: 4572; GeneCards: ST3GAL4; OMA:ST3GAL4 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11q24.2 Start 126,355,640 bp End 126,440,344 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 A4 Start 34,957,872 bp End 35,030,564 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left adrenal cortex right adrenal cortex left ovary right ovary rectum C1 segment right auricle tibial nerve transverse colon right testis Top expressed in Ileal epithelium jejunum gallbladder crypt of lieberkuhn of small intestine molar granulocyte parotid gland submandibular gland duodenum liver More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity glycosyltransferase activity sialyltransferase activity beta-galactoside (CMP) alpha-2,3-sialyltransferase activity monosialoganglioside sialyltransferase activity Cellular component integral component of membrane Golgi apparatus Golgi cisterna membrane extracellular region extracellular exosome membrane Golgi membrane Biological process cognition O-glycan processing keratan sulfate biosynthetic process oligosaccharide metabolic process protein N-linked glycosylation via asparagine protein glycosylation glycoprotein biosynthetic process glycolipid biosynthetic process oligosaccharide biosynthetic process lipid glycosylation sialylation protein sialylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6484 20443 Ensembl ENSG00000110080 ENSMUSG00000032038 UniProt Q11206 Q91Y74 RefSeq (mRNA) NM_001254757 NM_001254758 NM_001254759 NM_006278 NM_001348396 NM_001348398 NM_001348399 NM_001348400 NM_001348397 NM_009178 RefSeq (protein) NP_001241686 NP_001241687 NP_001241688 NP_006269 NP_001335325 NP_001335327 NP_001335328 NP_001335329 NP_001335326 NP_033204 Location (UCSC) Chr 11: 126.36 – 126.44 Mb Chr 9: 34.96 – 35.03 Mb PubMed search
Wikidata
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Further reading

• Kalyanaraman VS, Rodriguez V, Veronese F, et al. (1990). "Characterization of the secreted, native gp120 and gp160 of the human immunodeficiency virus type 1". AIDS Res. Hum. Retroviruses. 6 (3): 371–80. doi:10.1089/aid.1990.6.371. PMID 2187500.
• Pal R, Hoke GM, Sarngadharan MG (1989). "Role of oligosaccharides in the processing and maturation of envelope glycoproteins of human immunodeficiency virus type 1". Proc. Natl. Acad. Sci. U.S.A. 86 (9): 3384–8. Bibcode:1989PNAS...86.3384P. doi:10.1073/pnas.86.9.3384. PMC 287137. PMID 2541446.
• Dewar RL, Vasudevachari MB, Natarajan V, Salzman NP (1989). "Biosynthesis and processing of human immunodeficiency virus type 1 envelope glycoproteins: effects of monensin on glycosylation and transport". J. Virol. 63 (6): 2452–6. doi:10.1128/jvi.63.6.2452-2456.1989. PMC 250699. PMID 2542563.
• Kozarsky K, Penman M, Basiripour L, et al. (1989). "Glycosylation and processing of the human immunodeficiency virus type 1 envelope protein". J. Acquir. Immune Defic. Syndr. 2 (2): 163–9. PMID 2649653.
• Robinson WE, Montefiori DC, Mitchell WM (1988). "Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis". AIDS Res. Hum. Retroviruses. 3 (3): 265–82. doi:10.1089/aid.1987.3.265. PMID 2829950.
• Munro S (1995). "An investigation of the role of transmembrane domains in Golgi protein retention". EMBO J. 14 (19): 4695–704. doi:10.1002/j.1460-2075.1995.tb00151.x. PMC 394566. PMID 7588599.
• Chang ML, Eddy RL, Shows TB, Lau JT (1995). "Three genes that encode human beta-galactoside alpha 2,3-sialyltransferases. Structural analysis and chromosomal mapping studies". Glycobiology. 5 (3): 319–25. doi:10.1093/glycob/5.3.319. PMID 7655169.
• Sasaki K, Watanabe E, Kawashima K, et al. (1993). "Expression cloning of a novel Gal beta (1-3/1-4) GlcNAc alpha 2,3-sialyltransferase using lectin resistance selection". J. Biol. Chem. 268 (30): 22782–7. doi:10.1016/S0021-9258(18)41595-5. PMID 7901202.
• Basu SS, Basu M, Li Z, Basu S (1996). "Characterization of two glycolipid: alpha 2-3sialyltransferases, SAT-3 (CMP-NeuAc:nLcOse4Cer alpha 2-3sialyltransferase) and SAT-4 (CMP-NeuAc:GgOse4Cer alpha 2-3sialyltransferase), from human colon carcinoma (Colo 205) cell line". Biochemistry. 35 (16): 5166–74. doi:10.1021/bi960239l. PMID 8611500.
• Saito S, Yamashita S, Endoh M, et al. (2003). "Clinical significance of ST3Gal IV expression in human renal cell carcinoma". Oncol. Rep. 9 (6): 1251–5. doi:10.3892/or.9.6.1251. PMID 12375029.
• Grahn A, Larson G (2003). "Identification of nine alternatively spliced alpha2,3-sialyltransferase, ST3Gal IV, transcripts and analysis of their expression by RT-PCR and laser-induced fluorescent capillary electrophoresis (LIF-CE) in twenty-one human tissues". Glycoconj. J. 18 (10): 759–67. doi:10.1023/A:1021199300718. PMID 12441665. S2CID 11260655.
• Moody AM, North SJ, Reinhold B, et al. (2003). "Sialic acid capping of CD8beta core 1-O-glycans controls thymocyte-major histocompatibility complex class I interaction". J. Biol. Chem. 278 (9): 7240–6. doi:10.1074/jbc.M210468200. PMID 12459555.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Taniguchi A, Hioki M, Matsumoto K (2003). "Transcriptional regulation of human Galbeta1,3GalNAc/Galbeta1, 4GlcNAc alpha2,3-sialyltransferase (hST3Gal IV) gene in testis and ovary cell lines". Biochem. Biophys. Res. Commun. 301 (3): 764–8. doi:10.1016/S0006-291X(03)00041-X. PMID 12565846.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Higai K, Miyazaki N, Azuma Y, Matsumoto K (2007). "Interleukin-1beta induces sialyl Lewis X on hepatocellular carcinoma HuH-7 cells via enhanced expression of ST3Gal IV and FUT VI gene". FEBS Lett. 580 (26): 6069–75. doi:10.1016/j.febslet.2006.09.073. PMID 17054948. S2CID 9731951.
• Szabo R, Skropeta D, et al. (2017). "Advancement of Sialyltransferase Inhibitors: Therapeutic Challenges and Opportunities". Med. Res. Rev. 37 (2): 210–270. doi:10.1002/med.21407. PMID 27678392. S2CID 26280291.