ST13

This article is about the gene and protein. For the Star Trek 13 film, see Star Trek Beyond. For the ST13 postcode, see ST postcode area.

Hsc70-interacting protein also known as suppression of tumorigenicity 13 (ST13) is a protein that in humans is encoded by the ST13 gene.

ST13
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1UZS
Identifiers
Aliases	ST13, AAG2, FAM10A1, FAM10A4, HIP, HOP, HSPABP, HSPABP1, P48, PRO0786, SNC6, ST13 Hsp70 interacting protein
External IDs	OMIM: 606796; MGI: 1917606; HomoloGene: 2921; GeneCards: ST13; OMA:ST13 - orthologs
Gene location (Human) Chr. Chromosome 22 (human) Band 22q13.2 Start 40,824,535 bp End 40,856,639 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15|15 E1 Start 81,247,870 bp End 81,284,278 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left ovary Achilles tendon right ovary epithelium of colon ganglionic eminence body of uterus ventricular zone stromal cell of endometrium canal of the cervix gallbladder Top expressed in pineal gland tail of embryo neural layer of retina retinal pigment epithelium yolk sac genital tubercle ventricular zone abdominal wall epiblast dentate gyrus of hippocampal formation granule cell More reference expression data BioGPS n/a
Gene ontology Molecular function dATP binding unfolded protein binding protein-containing complex binding Hsp70 protein binding protein-macromolecule adaptor activity chaperone binding protein binding protein domain specific binding identical protein binding protein dimerization activity Cellular component extracellular exosome cytoplasm cytosol protein-containing complex Biological process protein homooligomerization protein folding negative regulation of protein refolding response to bacterium chaperone cofactor-dependent protein refolding protein homotetramerization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6767 70356 Ensembl ENSG00000100380 ENSMUSG00000022403 UniProt P50502 Q99L47 RefSeq (mRNA) NM_003932 NM_001278589 NM_133726 RefSeq (protein) NP_001265518 NP_003923 NP_598487 Location (UCSC) Chr 22: 40.82 – 40.86 Mb Chr 15: 81.25 – 81.28 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is an adaptor protein that mediates the association of the heat shock proteins HSP70 and HSP90. This protein has been shown to be involved in the assembly process of glucocorticoid receptor, which requires the assistance of multiple molecular chaperones. The expression of this gene is reported to be downregulated in colorectal carcinoma tissue suggesting that is a candidate tumor suppressor gene.

Further reading

• Prapapanich V, Chen S, Toran EJ, et al. (1996). "Mutational analysis of the hsp70-interacting protein Hip". Mol. Cell. Biol. 16 (11): 6200–7. doi:10.1128/MCB.16.11.6200. PMC 231623. PMID 8887650.
• Cao J, Cai X, Zheng L, et al. (1997). "Characterization of colorectal-cancer-related cDNA clones obtained by subtractive hybridization screening". J. Cancer Res. Clin. Oncol. 123 (8): 447–51. doi:10.1007/BF01372549. PMID 9292708. S2CID 42097617.
• Mo Y, Zheng S, Shen D (1998). "[Differential expression of HSU17714 gene in colorectal cancer and normal colonic mucosa]". Zhonghua Zhong Liu Za Zhi. 18 (4): 241–3. PMID 9387309.
• Johnson BD, Schumacher RJ, Ross ED, Toft DO (1998). "Hop modulates Hsp70/Hsp90 interactions in protein folding". J. Biol. Chem. 273 (6): 3679–86. doi:10.1074/jbc.273.6.3679. PMID 9452498.
• Zheng S, Cai X, Cao J, et al. (1998). "Screening and identification of down-regulated genes in colorectal carcinoma by subtractive hybridization: a method to identify putative tumor suppressor genes". Chin. Med. J. 110 (7): 543–7. PMID 9594214.
• Chen S, Smith DF (1999). "Hop as an adaptor in the heat shock protein 70 (Hsp70) and hsp90 chaperone machinery". J. Biol. Chem. 273 (52): 35194–200. doi:10.1074/jbc.273.52.35194. PMID 9857057.
• Scanlan MJ, Gordan JD, Williamson B, et al. (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". Int. J. Cancer. 83 (4): 456–64. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479. S2CID 21839750.
• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
• Morishima Y, Kanelakis KC, Silverstein AM, et al. (2000). "The Hsp organizer protein hop enhances the rate of but is not essential for glucocorticoid receptor folding by the multiprotein Hsp90-based chaperone system". J. Biol. Chem. 275 (10): 6894–900. doi:10.1074/jbc.275.10.6894. PMID 10702249.
• Rajapandi T, Greene LE, Eisenberg E (2000). "The molecular chaperones Hsp90 and Hsc70 are both necessary and sufficient to activate hormone binding by glucocorticoid receptor". J. Biol. Chem. 275 (29): 22597–604. doi:10.1074/jbc.M002035200. PMID 10781595.
• Agarraberes FA, Dice JF (2002). "A molecular chaperone complex at the lysosomal membrane is required for protein translocation". J. Cell Sci. 114 (Pt 13): 2491–9. doi:10.1242/jcs.114.13.2491. PMID 11559757.
• Velten M, Gomez-Vrielynck N, Chaffotte A, Ladjimi MM (2002). "Domain structure of the HSC70 cochaperone, HIP". J. Biol. Chem. 277 (1): 259–66. doi:10.1074/jbc.M106881200. PMID 11687574.
• Fan GH, Yang W, Sai J, Richmond A (2002). "Hsc/Hsp70 interacting protein (hip) associates with CXCR2 and regulates the receptor signaling and trafficking". J. Biol. Chem. 277 (8): 6590–7. doi:10.1074/jbc.M110588200. PMC 2665275. PMID 11751889.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Nelson GM, Prapapanich V, Carrigan PE, et al. (2005). "The heat shock protein 70 cochaperone hip enhances functional maturation of glucocorticoid receptor". Mol. Endocrinol. 18 (7): 1620–30. doi:10.1210/me.2004-0054. PMID 15071092.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.