SSR-180,575

SSR-180,575 is a drug which acts as a selective agonist at the peripheral benzodiazepine receptor, also known as the mitochondrial 18 kDa translocator protein or TSPO. It has been shown to have neuroprotective and cardioprotective effects and to stimulate steroidogenesis of pregnenolone in the brain, which may be linked to its neuroprotective action.[1][2][3][4]

SSR-180,575
SSR-180,575.svg
Clinical data
ATC code
  • None
Identifiers
  • 7-Chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC21H19ClN4O2
Molar mass394.86 g·mol−1
3D model (JSmol)
  • Cn2c3cc(Cl)ccc3c1c2c(=O)n(nc1CC(=O)N(C)C)-c4ccccc4
  • InChI=1S/C21H19ClN4O2/c1-24(2)18(27)12-16-19-15-10-9-13(22)11-17(15)25(3)20(19)21(28)26(23-16)14-7-5-4-6-8-14/h4-11H,12H2,1-3H3
  • Key:HJSQVJOROCIILI-UHFFFAOYSA-N
 ☒NcheckY (what is this?)  (verify)

See alsoEdit

ReferencesEdit

  1. ^ Ferzaz B, Brault E, Bourliaud G, Robert JP, Poughon G, Claustre Y, et al. (June 2002). "SSR180575 (7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide), a peripheral benzodiazepine receptor ligand, promotes neuronal survival and repair". The Journal of Pharmacology and Experimental Therapeutics. 301 (3): 1067–78. doi:10.1124/jpet.301.3.1067. PMID 12023539.
  2. ^ Leducq N, Bono F, Sulpice T, Vin V, Janiak P, Fur GL, et al. (September 2003). "Role of peripheral benzodiazepine receptors in mitochondrial, cellular, and cardiac damage induced by oxidative stress and ischemia-reperfusion". The Journal of Pharmacology and Experimental Therapeutics. 306 (3): 828–37. doi:10.1124/jpet.103.052068. PMID 12928523.
  3. ^ Kunduzova OR, Escourrou G, De La Farge F, Salvayre R, Séguélas MH, Leducq N, et al. (August 2004). "Involvement of peripheral benzodiazepine receptor in the oxidative stress, death-signaling pathways, and renal injury induced by ischemia-reperfusion". Journal of the American Society of Nephrology. 15 (8): 2152–60. doi:10.1097/01.ASN.0000133563.41148.74. PMID 15284300.
  4. ^ Veenman L, Gavish M (June 2006). "The peripheral-type benzodiazepine receptor and the cardiovascular system. Implications for drug development". Pharmacology & Therapeutics. 110 (3): 503–24. doi:10.1016/j.pharmthera.2005.09.007. PMID 16337685.