Signal peptide peptidase-like 2A, also known as SPPL2A, is a human gene.[5]

SPPL2A
Identifiers
AliasesSPPL2A, IMP3, PSL2, signal peptide peptidase like 2A, IMD86
External IDsOMIM: 608238; MGI: 1913802; HomoloGene: 36411; GeneCards: SPPL2A; OMA:SPPL2A - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_032802

NM_023220

RefSeq (protein)

NP_116191

NP_075709

Location (UCSC)Chr 15: 50.7 – 50.77 MbChr 2: 126.89 – 126.93 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

edit

This gene is a member of the signal peptide peptidase-like protease (SPPL) family and encodes a lysosomal/late endosomal membrane protein[6] with the conserved active site motifs 'YD' and 'GxGD' in adjacent transmembrane domains (TMDs). This protein plays a role in innate and adaptive immunity by cleaving TNFα in activated dendritic cells.[7][8] A pseudogene of this gene also lies on chromosome 15.[5]

References

edit
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000138600Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027366Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: SPPL2A signal peptide peptidase-like 2A".
  6. ^ Behnke J, Schneppenheim J, Koch-Nolte F, Haag F, Saftig P, Schröder B (2011). "Signal-peptide-peptidase-like 2a (SPPL2a) is targeted to lysosomes/late endosomes by a tyrosine motif in its C-terminal tail". FEBS Letters. 585 (19): 2951–7. doi:10.1016/j.febslet.2011.08.043. PMID 21896273.
  7. ^ Friedmann E, Hauben E, Maylandt K, et al. (2006). "SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production". Nat. Cell Biol. 8 (8): 843–8. doi:10.1038/ncb1440. PMID 16829952. S2CID 129089.
  8. ^ Fluhrer R, Grammer G, Israel L, et al. (2006). "A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b" (PDF). Nat. Cell Biol. 8 (8): 894–6. doi:10.1038/ncb1450. PMID 16829951. S2CID 23712486.

Further reading

edit