Pancreatic secretory trypsin inhibitor (PSTI) also known as serine protease inhibitor Kazal-type 1 (SPINK1) or tumor-associated trypsin inhibitor (TATI) is a protein that in humans is encoded by the SPINK1 gene.[5]

SPINK1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSPINK1, PCTT, PSTI, Spink3, TATI, TCP, serine peptidase inhibitor, Kazal type 1, serine peptidase inhibitor Kazal type 1
External IDsOMIM: 167790; MGI: 106202; HomoloGene: 68300; GeneCards: SPINK1; OMA:SPINK1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003122
NM_001354966
NM_001379610

NM_009258

RefSeq (protein)

NP_003113
NP_001341895
NP_001366539

NP_033284

Location (UCSC)Chr 5: 147.82 – 147.83 MbChr 18: 43.86 – 43.87 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mutations in SPINK1 has been associated with hereditary pancreatitis and tropical pancreatitis. Trypsinogen is normally created and stored an inactive zymogen of trypsin in the pancreas, but occasionally will autoactivate itself. PSTI serves to cleave prematurely activated trypsin to prevent the enzyme from causing cellular damage to the organ. Without the function of PSTI, the pancreas is subject to repeated episodes of damage.[6]

It has also been associated with prostate cancer.[7]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164266Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024503Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: SPINK1 serine peptidase inhibitor, Kazal type 1".
  6. ^ Schneider, A. "SPINK1 - serine peptidase inhibitor, Kazal type 1". Wikigenes.
  7. ^ Tomlins SA, Rhodes DR, Yu J, Varambally S, Mehra R, Perner S, et al. (Jun 2008). "The role of SPINK1 in ETS rearrangement-negative prostate cancers". Cancer Cell. 13 (6): 519–28. doi:10.1016/j.ccr.2008.04.016. PMC 2732022. PMID 18538735.

Further reading

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