SP-350 may refer to:
- SP-350 Denise, a small submarine designed to hold two people capable of exploring depths of up to 400 metres invented by Jacques-Yves Cousteau
- SP-350 (Brazil), a State highway in Brazil
- Olympus SP-350, 8-megapixel compact digital camera
- USS Roselle (SP-350), a ship that served both as a tug and as minesweeper
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