Transcription factor SOX-14 is a protein that in humans is encoded by the SOX14 gene.[5][6]

SOX14
Identifiers
AliasesSOX14, SOX28, SRY-box 14, SRY-box transcription factor 14
External IDsOMIM: 604747; MGI: 98362; HomoloGene: 31224; GeneCards: SOX14; OMA:SOX14 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004189

NM_011440

RefSeq (protein)

NP_004180

NP_035570

Location (UCSC)Chr 3: 137.76 – 137.77 MbChr 9: 99.76 – 99.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

edit

This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. Mutations in this gene are suggested to be responsible for the limb defects associated with blepharophimosis, ptosis, epicanthus inversus syndrome (BPES) and Mobius syndrome.[6]

References

edit
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000168875Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000053747Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Arsic N, Rajic T, Stanojcic S, Goodfellow PN, Stevanovic M (Mar 1999). "Characterisation and mapping of the human SOX14 gene". Cytogenetics and Cell Genetics. 83 (1–2): 139–46. doi:10.1159/000015149. PMID 9925951. S2CID 24812709.
  6. ^ a b "Entrez Gene: SOX14 SRY (sex determining region Y)-box 14".

Further reading

edit