SMCR7L

Mitochondrial dynamic protein MID51 (MID51) also known as mitochondrial elongation factor 1 (MIEF1) or Smith-Magenis syndrome chromosome region candidate gene 7 protein-like (SMCR7L) is a protein that in humans is encoded by the SMCR7L gene.

MIEF1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4NXT, 4NXU, 4NXV, 4NXW, 4NXX
Identifiers
Aliases	MIEF1, HSU79252, MID51, SMCR7L, dJ1104E15.3, mitochondrial elongation factor 1, AltMIEF1-MP
External IDs	OMIM: 615497; MGI: 2146020; HomoloGene: 10374; GeneCards: MIEF1; OMA:MIEF1 - orthologs
Gene location (Human) Chr. Chromosome 22 (human) Band 22q13.1 Start 39,499,432 bp End 39,518,132 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15|15 E1 Start 80,118,219 bp End 80,137,572 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm secondary oocyte right testis left testis vena cava endothelial cell body of tongue pancreatic ductal cell cerebellar vermis ventricular zone Top expressed in zygote spermatocyte spermatid genital tubercle tail of embryo hand superior cervical ganglion neural tube lacrimal gland interventricular septum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding ADP binding protein binding GDP binding identical protein binding Cellular component integral component of membrane mitochondrial outer membrane peroxisome membrane mitochondrion mitochondrial matrix mitochondrial large ribosomal subunit Biological process mitochondrial fusion positive regulation of mitochondrial fission mitochondrial fission positive regulation of protein targeting to membrane regulation of translation ribosome biogenesis positive regulation of mitochondrial translation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54471 239555 Ensembl ENSG00000100335 ENSMUSG00000022412 UniProt L0R8F8 Q8BGV8 RefSeq (mRNA) NM_001304564 NM_013298 NM_019008 NM_001394030 NM_178719 NM_001357659 NM_001357660 RefSeq (protein) NP_001291493 NP_061881 NP_848834 NP_001344588 NP_001344589 Location (UCSC) Chr 22: 39.5 – 39.52 Mb Chr 15: 80.12 – 80.14 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

The SMCR7L gene codes for a protein that has been called MiD51/MIEF1 and shown to regulate mitochondrial fission by interacting with the proteins Drp1 and FIS1.

Further reading

• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
• Hartley JL; Temple GF; Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.