Secreted Ly-6/uPAR-related protein 1 is a protein that in humans is encoded by the SLURP1 gene.[5][6][7] It exerts anti-inflammatory effects, acts as a tumor suppressor, and antagonizes nicotinic receptors.[8]

SLURP1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSLURP1, ANUP, ARS, ArsB, LY6LS, MDM, secreted LY6/PLAUR domain containing 1, LY6-MT
External IDsOMIM: 606119; MGI: 1930923; HomoloGene: 10710; GeneCards: SLURP1; OMA:SLURP1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_020427

NM_020519

RefSeq (protein)

NP_065160

NP_065265

Location (UCSC)Chr 8: 142.74 – 142.74 MbChr 15: 74.6 – 74.6 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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The protein encoded by this gene is a member of the Ly6/uPAR family but lacks a GPI-anchoring signal sequence. It is secreted into the blood[6] and is also sometimes found in semen when extracted into the female zygote which binds to the α7-acetylcholine receptor.[8] It is shown to act as an endogenous tumor suppressor by reducing cell migration and invasion by mediating its own anti-tumor effect and by antagonizing the pro-malignant effects of nicotine.[8]

Mutations in this gene have been associated with Mal de Meleda, a rare autosomal recessive skin disorder characterized by an inflammatory palmoplantar hyperkeratosis. This is the consequence of a loss of SLURP1 which leads to a dysfunctional epithelial differentiation[9] and an increased secretion of the inflammatory cytokines TNFα, IL1, IL-6, and IL-8.[10][11]

This gene maps to the same chromosomal region as several members of the Ly6/uPAR family of glycoprotein receptors.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000126233Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022596Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Fischer J, Bouadjar B, Heilig R, Huber M, Lefèvre C, Jobard F, Macari F, Bakija-Konsuo A, Ait-Belkacem F, Weissenbach J, Lathrop M, Hohl D, Prud'homme JF (April 2001). "Mutations in the gene encoding SLURP-1 in Mal de Meleda". Human Molecular Genetics. 10 (8): 875–80. doi:10.1093/hmg/10.8.875. PMID 11285253.
  6. ^ a b Adermann K, Wattler F, Wattler S, Heine G, Meyer M, Forssmann WG, Nehls M (April 1999). "Structural and phylogenetic characterization of human SLURP-1, the first secreted mammalian member of the Ly-6/uPAR protein superfamily". Protein Science. 8 (4): 810–9. doi:10.1110/ps.8.4.810. PMC 2144295. PMID 10211827.
  7. ^ a b "Entrez Gene: SLURP1 secreted LY6/PLAUR domain containing 1".
  8. ^ a b c Throm VM, Männle D, Giese T, Bauer AS, Gaida MM, Kopitz J, Bruckner T, Plaschke K, Grekova SP, Felix K, Hackert T, Giese NA, Strobel O (February 2018). "Endogenous CHRNA7-ligand SLURP1 as a potential tumor suppressor and anti-nicotinic factor in pancreatic cancer". Oncotarget. 9 (14): 11734–11751. doi:10.18632/oncotarget.24312. PMC 5837762. PMID 29545933.
  9. ^ Favre B, Plantard L, Aeschbach L, Brakch N, Christen-Zaech S, de Viragh PA, Sergeant A, Huber M, Hohl D (February 2007). "SLURP1 is a late marker of epidermal differentiation and is absent in Mal de Meleda". The Journal of Investigative Dermatology. 127 (2): 301–8. doi:10.1038/sj.jid.5700551. PMID 17008884.
  10. ^ Swamynathan S, Buela KA, Kinchington P, Lathrop KL, Misawa H, Hendricks RL, Swamynathan SK (December 2012). "Klf4 regulates the expression of Slurp1, which functions as an immunomodulatory peptide in the mouse cornea". Investigative Ophthalmology & Visual Science. 53 (13): 8433–46. doi:10.1167/iovs.12-10759. PMC 4113333. PMID 23139280.
  11. ^ Chernyavsky AI, Galitovskiy V, Shchepotin IB, Grando SA (2014). "Anti-inflammatory effects of the nicotinergic peptides SLURP-1 and SLURP-2 on human intestinal epithelial cells and immunocytes". BioMed Research International. 2014: 609086. doi:10.1155/2014/609086. PMC 4024406. PMID 24877120.

Further reading

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