Sodium/myo-inositol cotransporter is a protein that in humans is encoded by the SLC5A3 gene .[ 5] [ 6]
Expression of the myo-inositol transport protein is regulated by osmotic stress .[ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000198743 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000089774 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Berry GT, Mallee JJ, Kwon HM, Rim JS, Mulla WR, Muenke M, Spinner NB (Jul 1995). "The human osmoregulatory Na+/myo-inositol cotransporter gene (SLC5A3): molecular cloning and localization to chromosome 21" . Genomics . 25 (2): 507–13. doi :10.1016/0888-7543(95)80052-N PMID 7789985 . ^ "Entrez Gene: SLC5A3 solute carrier family 5 (inositol transporters), member 3" .^ Lee SD, Choi SY, Lim SW, Lamitina ST, Ho SN, Go WY, Kwon HM (2011). "TonEBP stimulates multiple cellular pathways for adaptation to hypertonic stress: Organic osmolyte-dependent and -independent pathways" . AJP: Renal Physiology . 300 (3): F707–F715. doi :10.1152/ajprenal.00227.2010 . PMC 3064130 PMID 21209002 .
Kwon HM, Yamauchi A, Uchida S, et al. (1992). "Cloning of the cDNa for a Na+/myo-inositol cotransporter, a hypertonicity stress protein" . J. Biol. Chem . 267 (9): 6297–301. doi :10.1016/S0021-9258(18)42695-6 PMID 1372904 . Berry GT, Mallee JJ, Blouin JL, Antonarakis SE (1996). "The 21q22.1 STS marker, VN02 (EST00541 cDNA), is part of the 3' sequence of the human Na+/myo-inositol cotransporter (SLC5A3) gene". Cytogenet. Cell Genet . 73 (1–2): 77–8. doi :10.1159/000134311 . PMID 8646889 . Mallee JJ, Atta MG, Lorica V, et al. (1998). "The structural organization of the human Na+/myo-inositol cotransporter (SLC5A3) gene and characterization of the promoter" . Genomics . 46 (3): 459–65. doi :10.1006/geno.1997.5055 PMID 9441750 . Porcellati F, Hlaing T, Togawa M, et al. (1998). "Human Na(+)-myo-inositol cotransporter gene: alternate splicing generates diverse transcripts". Am. J. Physiol . 274 (5 Pt 1): C1215–25. doi :10.1152/ajpcell.1998.274.5.C1215 . PMID 9612208 . S2CID 22626824 . Rim JS, Atta MG, Dahl SC, et al. (1998). "Transcription of the Sodium/myo-Inositol Cotransporter Gene Is Regulated by Multiple Tonicity-responsive Enhancers Spread over 50 Kilobase Pairs in the 5′-Flanking Region" . J. Biol. Chem . 273 (32): 20615–21. doi :10.1074/jbc.273.32.20615 PMC 2365891 PMID 9685419 . Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21" . Nature . 405 (6784): 311–9. Bibcode :2000Natur.405..311H . doi :10.1038/35012518 PMID 10830953 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions" . Genome Res . 14 (9): 1711–8. doi :10.1101/gr.2435604 . PMC 515316 PMID 15342556 . Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes" . Genome Res . 16 (1): 55–65. doi :10.1101/gr.4039406 . PMC 1356129 PMID 16344560 . Thangaraju M, Gopal E, Martin PM, et al. (2007). "SLC5A8 triggers tumor cell apoptosis through pyruvate-dependent inhibition of histone deacetylases" . Cancer Res . 66 (24): 11560–4. doi :10.1158/0008-5472.CAN-06-1950 PMID 17178845 .
