Organic solute transporter alpha , also known as OST-alpha , is a protein which in humans is encoded by the SLC51A gene .[ 5] [ 6]
OST-alpha together with OST-beta is able to transport estrone sulfate , taurocholate , digoxin , and prostaglandin E2 across cell membranes .[ 6] [ 7] heterodimer , but not the individual subunits, stimulates sodium-independent bile acid uptake.[ 7] bile acid transport.[ 8]
OST-alpha and OST-alpha have high expression in the testis, colon, liver, small intestine, kidney, ovary, and adrenal gland.[ 6]
^ a b c GRCh38: Ensembl release 89: ENSG00000163959 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035699 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Entrez Gene: OSTalpha organic solute transporter alpha" .^ a b c Seward DJ, Koh AS, Boyer JL, Ballatori N (July 2003). "Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta" . J. Biol. Chem . 278 (30): 27473–82. doi :10.1074/jbc.M301106200 PMID 12719432 . ^ a b Dawson PA, Hubbert M, Haywood J, Craddock AL, Zerangue N, Christian WV, Ballatori N (February 2005). "The Heteromeric Organic Solute Transporter α-β, Ostα-Ostβ, Is an Ileal Basolateral Bile Acid Transporter" . J. Biol. Chem . 280 (8): 6960–8. doi :10.1074/jbc.M412752200 PMC 1224727 PMID 15563450 . ^ Rao A, Haywood J, Craddock AL, Belinsky MG, Kruh GD, Dawson PA (March 2008). "The organic solute transporter α-β, Ostα-Ostβ, is essential for intestinal bile acid transport and homeostasis" . Proc. Natl. Acad. Sci. U.S.A . 105 (10): 3891–6. Bibcode :2008PNAS..105.3891R . doi :10.1073/pnas.0712328105 PMC 2268840 PMID 18292224 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Seward DJ, Koh AS, Boyer JL, Ballatori N (2003). "Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta" . J. Biol. Chem . 278 (30): 27473–82. doi :10.1074/jbc.M301106200 PMID 12719432 . Dawson PA, Hubbert M, Haywood J, et al. (2005). "The Heteromeric Organic Solute Transporter α-β, Ostα-Ostβ, Is an Ileal Basolateral Bile Acid Transporter" . J. Biol. Chem . 280 (8): 6960–8. doi :10.1074/jbc.M412752200 PMC 1224727 PMID 15563450 . Lee H, Zhang Y, Lee FY, et al. (2006). "FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine" . J. Lipid Res . 47 (1): 201–14. doi :10.1194/jlr.M500417-JLR200 PMID 16251721 . Landrier JF, Eloranta JJ, Vavricka SR, Kullak-Ublick GA (2006). "The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes". Am. J. Physiol. Gastrointest. Liver Physiol . 290 (3): G476–85. doi :10.1152/ajpgi.00430.2005 . PMID 16269519 . S2CID 8687386 . Ballatori N, Christian WV, Lee JY, et al. (2005). "OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia" . Hepatology . 42 (6): 1270–9. doi :10.1002/hep.20961 PMID 16317684 . S2CID 55829915 . Boyer JL, Trauner M, Mennone A, et al. (2006). "Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents". Am. J. Physiol. Gastrointest. Liver Physiol . 290 (6): G1124–30. doi :10.1152/ajpgi.00539.2005 . PMID 16423920 . S2CID 86156271 . Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration" . Cell . 125 (4): 801–14. doi :10.1016/j.cell.2006.03.032 PMID 16713569 . S2CID 13709685 . Sun AQ, Balasubramaniyan N, Xu K, et al. (2007). "Protein-protein interactions and membrane localization of the human organic solute transporter". Am. J. Physiol. Gastrointest. Liver Physiol . 292 (6): G1586–93. doi :10.1152/ajpgi.00457.2006 . PMID 17332473 .
