SLC38A1

Sodium-coupled neutral amino acid transporter 1 is a protein that in humans is encoded by the SLC38A1 gene.

SLC38A1
Identifiers
Aliases	SLC38A1, ATA1, NAT2, SAT1, SNAT1, solute carrier family 38 member 1
External IDs	OMIM: 608490; MGI: 2145895; HomoloGene: 12745; GeneCards: SLC38A1; OMA:SLC38A1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12q13.11 Start 46,183,063 bp End 46,270,017 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15|15 F1 Start 96,469,299 bp End 96,540,794 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lateral nuclear group of thalamus seminal vesicula superficial temporal artery mucosa of sigmoid colon middle temporal gyrus pars compacta body of tongue Brodmann area 23 cerebellar vermis external globus pallidus Top expressed in deep cerebellar nuclei inferior colliculi retinal pigment epithelium habenula dorsal tegmental nucleus medial vestibular nucleus superior colliculus cerebellar vermis pontine nuclei ventral tegmental area More reference expression data BioGPS More reference expression data
Gene ontology Molecular function neutral amino acid transmembrane transporter activity protein binding amino acid:sodium symporter activity symporter activity L-amino acid transmembrane transporter activity amino acid transmembrane transporter activity Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane extracellular exosome Biological process sodium ion transport neurotransmitter uptake amino acid transport neutral amino acid transport ion transport L-alpha-amino acid transmembrane transport amino acid transmembrane transport L-amino acid transport transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 81539 105727 Ensembl ENSG00000111371 ENSMUSG00000023169 UniProt Q9H2H9 Q8K2P7 RefSeq (mRNA) NM_001077484 NM_001278387 NM_001278388 NM_001278389 NM_001278390 NM_030674 NM_001166456 NM_001166458 NM_134086 RefSeq (protein) NP_001070952 NP_001265316 NP_001265317 NP_001265318 NP_001265319 NP_109599 NP_001159928 NP_001159930 NP_598847 Location (UCSC) Chr 12: 46.18 – 46.27 Mb Chr 15: 96.47 – 96.54 Mb PubMed search
Wikidata
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Amino acid transporters play essential roles in the uptake of nutrients, production of energy, chemical metabolism, detoxification, and neurotransmitter cycling. SLC38A1 is an important transporter of glutamine, an intermediate in the detoxification of ammonia and the production of urea. Glutamine serves as a precursor for the synaptic transmitter, glutamate (Gu et al., 2001).[supplied by OMIM]

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Gu S, Roderick HL, Camacho P, Jiang JX (2001). "Characterization of an N-system amino acid transporter expressed in retina and its involvement in glutamine transport". J. Biol. Chem. 276 (26): 24137–44. doi:10.1074/jbc.M009003200. PMID 11325958.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Melone M, Quagliano F, Barbaresi P, et al. (2004). "Localization of the glutamine transporter SNAT1 in rat cerebral cortex and neighboring structures, with a note on its localization in human cortex". Cereb. Cortex. 14 (5): 562–74. doi:10.1093/cercor/bhh018. PMID 15054072.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Kondoh N, Imazeki N, Arai M, et al. (2007). "Activation of a system A amino acid transporter, ATA1/SLC38A1, in human hepatocellular carcinoma and preneoplastic liver tissues". Int. J. Oncol. 31 (1): 81–7. doi:10.3892/ijo.31.1.81. PMID 17549407.