Mitochondrial 2-oxodicarboxylate carrier

(Redirected from SLC25A21)

Mitochondrial 2-oxodicarboxylate carrier also known as solute carrier family 25 member 21 (SLC25A21) is a protein that in humans is encoded by the SLC25A21 gene.[5]

SLC25A21
Identifiers
AliasesSLC25A21, ODC, ODC1, solute carrier family 25 member 21, MTDPS18
External IDsOMIM: 607571; MGI: 2445059; HomoloGene: 6988; GeneCards: SLC25A21; OMA:SLC25A21 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001171170
NM_030631

NM_001167976
NM_172577

RefSeq (protein)

NP_001164641
NP_085134

NP_001161448
NP_766165

Location (UCSC)Chr 14: 36.68 – 37.17 MbChr 12: 56.76 – 57.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

It is a homolog of the S. cerevisiae ODC proteins, mitochondrial carriers that transport C5-C7 oxodicarboxylates across inner mitochondrial membranes. One of the species transported by ODC is 2-oxoadipate, a common intermediate in the catabolism of lysine, tryptophan, and hydroxylysine in mammals. Within mitochondria, 2-oxoadipate is converted into acetyl-CoA.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000183032Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035472Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21". Retrieved 2011-12-04.

Further reading

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