SLC15A2

Solute carrier family 15 (H+/peptide transporter), member 2, also known as SLC15A2, is a human gene.

SLC15A2
Identifiers
Aliases	SLC15A2, PEPT2, solute carrier family 15 member 2
External IDs	OMIM: 602339; MGI: 1890457; HomoloGene: 56912; GeneCards: SLC15A2; OMA:SLC15A2 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3q13.33 Start 121,894,401 bp End 121,944,188 bp
Gene location (Mouse) Chr. Chromosome 16 (mouse) Band 16|16 B3 Start 36,570,539 bp End 36,605,324 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in nasal epithelium bronchial epithelial cell palpebral conjunctiva corpus epididymis mucosa of paranasal sinus parotid gland olfactory zone of nasal mucosa seminal vesicula trachea epithelium of nasopharynx Top expressed in epithelium of lens conjunctival fornix olfactory epithelium right kidney vestibular membrane of cochlear duct human kidney neural layer of retina parotid gland Epithelium of choroid plexus seminal vesicula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptide:proton symporter activity protein binding symporter activity transporter activity transmembrane transporter activity oligopeptide transmembrane transporter activity dipeptide transmembrane transporter activity peptide transmembrane transporter activity Cellular component integral component of membrane plasma membrane integral component of plasma membrane extracellular exosome membrane Biological process protein transport peptide transport oligopeptide transport ion transport transmembrane transport transport dipeptide transmembrane transport oligopeptide transmembrane transport proton transmembrane transport xenobiotic detoxification by transmembrane export across the plasma membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6565 57738 Ensembl ENSG00000163406 ENSMUSG00000022899 UniProt Q16348 Q9ES07 RefSeq (mRNA) NM_001145998 NM_021082 NM_001145899 NM_021301 RefSeq (protein) NP_001139470 NP_066568 n/a Location (UCSC) Chr 3: 121.89 – 121.94 Mb Chr 16: 36.57 – 36.61 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

See also

• Solute carrier family

Further reading

• Liu W, Liang R, Ramamoorthy S, et al. (1995). "Molecular cloning of PEPT 2, a new member of the H+/peptide cotransporter family, from human kidney". Biochim. Biophys. Acta. 1235 (2): 461–6. doi:10.1016/0005-2736(95)80036-F. PMID 7756356.
• Döring F, Martini C, Walter J, Daniel H (2002). "Importance of a small N-terminal region in mammalian peptide transporters for substrate affinity and function". J. Membr. Biol. 186 (2): 55–62. doi:10.1007/s00232-001-0135-9. PMID 11944083. S2CID 11211548.
• Alcorn J, Lu X, Moscow JA, McNamara PJ (2002). "Transporter gene expression in lactating and nonlactating human mammary epithelial cells using real-time reverse transcription-polymerase chain reaction". J. Pharmacol. Exp. Ther. 303 (2): 487–96. doi:10.1124/jpet.102.038315. PMID 12388627. S2CID 16195525.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Groneberg DA (2003). "[Expression, localization and functional aspects of the peptide transporter PEPT2 in the normal respiratory tract and in cystic fibrosis]". Pneumologie (Stuttgart, Germany). 57 (2): 104–5. doi:10.1055/s-2003-37158. PMID 12579467.
• Terada T, Irie M, Okuda M, Inui K (2004). "Genetic variant Arg57His in human H+/peptide cotransporter 2 causes a complete loss of transport function". Biochem. Biophys. Res. Commun. 316 (2): 416–20. doi:10.1016/j.bbrc.2004.02.063. PMID 15020234.
• Pinsonneault J, Nielsen CU, Sadée W (2005). "Genetic variants of the human H+/dipeptide transporter PEPT2: analysis of haplotype functions". J. Pharmacol. Exp. Ther. 311 (3): 1088–96. doi:10.1124/jpet.104.073098. PMID 15282265. S2CID 12947228.
• Bahadduri PM, D'Souza VM, Pinsonneault JK, et al. (2005). "Functional characterization of the peptide transporter PEPT2 in primary cultures of human upper airway epithelium". Am. J. Respir. Cell Mol. Biol. 32 (4): 319–25. doi:10.1165/rcmb.2004-0322OC. PMID 15626774.
• Zhang EY, Emerick RM, Pak YA, et al. (2005). "Comparison of human and monkey peptide transporters: PEPT1 and PEPT2". Mol. Pharm. 1 (3): 201–10. doi:10.1021/mp0499712. PMID 15981923.
• Noshiro R, Anzai N, Sakata T, et al. (2006). "The PDZ domain protein PDZK1 interacts with human peptide transporter PEPT2 and enhances its transport activity". Kidney Int. 70 (2): 275–82. doi:10.1038/sj.ki.5001522. PMID 16738539.
• Søndergaard H, Bravo S, Nielsen CU, et al. (2008). "Cloning of the pig PEPT2 (pPEPT2) and characterization of the effects of epidermal growth factor (EGF) on pPEPT2-mediated peptide uptake in the renal porcine cell line LLC-PK1". Eur. J. Pharm. Sci. 33 (4): 332–42. doi:10.1016/j.ejps.2008.01.001. PMID 18295462.